PMID: 8608943Apr 15, 1996Paper

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation

Genes & Development
G Cheng, D Baltimore

Abstract

We describe a new signal mediator of NF-kappaB activation, TANK, that acts in a pathway common to two surface receptors CD40 and TNFR II. TRAF family members interact directly with these receptors. Using the yeast two-hybrid system, TANK was identified as an intracellular protein without previous homologs that interacts with all three known TRAF family members. In cotransfection experiments, TANK and TRAF2 activate NF-kappaB synergistically, requiring both the amino-terminal portion of TANK and the ring finger domain of TRAF2. TANK has a negatively acting carboxyl terminus and is constitutively inactive, but TRAF2 binding overcomes the internal inhibitory influence. We propose that ligand binding to CD40 or TNFR II leads to the formation of a TRAF2/TANK complex, mediating NF-kappaB activation.

References

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S J ElledgeR W Davis
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Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·G ChengD Baltimore
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Citations

Nov 26, 2002·Journal of Molecular Recognition : JMR·Kathryn R Ely, Chenglong Li
May 7, 2004·Veterinary Immunology and Immunopathology·Sayed Abdalla AbdallaHaruo Matsuda
Oct 6, 1999·Molecular Immunology·W G van EyndhovenS Lederman
Mar 24, 1998·Immunology Today·M J May, S Ghosh
May 9, 2001·Biochimica Et Biophysica Acta·R T Peters, T Maniatis
Feb 13, 2001·The International Journal of Biochemistry & Cell Biology·H Wajant, P Scheurich
Jun 6, 2003·Cytokine & Growth Factor Reviews·Paul W DempseyGenhong Cheng
Jun 24, 1999·Cytokine & Growth Factor Reviews·H WajantP Scheurich
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kristopher ClarkPhilip Cohen
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A SinghB B Aggarwal
May 21, 2010·Molecular Biology of the Cell·Wanqiao ZhangFuchu He
Apr 19, 2006·Genes & Development·Bach-Cuc NguyenG Paolo Dotto
Jun 24, 2003·Genome Research·John C ReedUNKNOWN GSL Members
Jan 10, 2002·Genome Research·Reinhard HoffmannFritz Melchers
Jan 1, 1997·Journal of Viral Hepatitis·F Balkwill
Nov 2, 2005·Molecular and Cellular Biology·Clare C DaviesAristides G Eliopoulos
Apr 5, 2000·Molecular Pathology : MP·K R BaumforthP G Murray
Dec 28, 1999·Annual Review of Cell and Developmental Biology·R H Arch, C B Thompson
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Dec 29, 2009·Journal of Neuroinflammation·Antero SalminenJohanna Ojala

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