Tannic acid-modified silver nanoparticles for wound healing: the importance of size

International Journal of Nanomedicine
Piotr OrlowskiMalgorzata Krzyzowska

Abstract

Silver nanoparticles (AgNPs) have been shown to promote wound healing and to exhibit antimicrobial properties against a broad range of bacteria. In our previous study, we prepared tannic acid (TA)-modified AgNPs showing a good toxicological profile and immunomodulatory properties useful for potential dermal applications. In this study, in vitro scratch assay, antimicrobial tests, modified lymph node assay as well as a mouse splint wound model were used to access the wound healing potential of TA-modified and unmodified AgNPs. TA-modified but not unmodified AgNPs exhibited effective antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli and stimulated migration of keratinocytes in vitro. The tests using the mouse splint wound model showed that TA-modified 33 and 46 nm AgNPs promoted better wound closure, epithelialization, angiogenesis and formation of the granulation tissue. Additionally, AgNPs elicited expression of VEGF-α, PDGF-β and TGF-β1 cytokines involved in wound healing more efficiently in comparison to control and TA-treated wounds. However, both the lymph node assay and the wound model showed that TA-modified AgNPs sized 13 nm can elicit strong inflammatory response not only ...Continue Reading

Citations

Dec 24, 2019·Nanomedicine·Agnieszka Małgorzata PudlarzJanusz Szemraj
Mar 3, 2020·Journal of Basic Microbiology·Hafiz Muhammad TahirGhulam Murtaza
Aug 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Namitha K PremanRenjith P Johnson
Aug 9, 2020·International Journal of Nanomedicine·Piotr OrlowskiMalgorzata Krzyzowska
Jul 14, 2018·International Journal of Molecular Sciences·Shana J CameronWilliam G Willmore
Jan 24, 2019·International Journal of Molecular Sciences·Chengzhu LiaoSie Chin Tjong
Apr 3, 2020·International Journal of Molecular Sciences·Zannatul Ferdous, Abderrahim Nemmar
Oct 19, 2019·IET Nanobiotechnology·Debalina BhattacharyaMainak Mukhopadhyay
Mar 3, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wen ShiBin Duan
Jun 3, 2021·International Journal of Molecular Sciences·Shirin KouhpayehPooyan Makvandi
Jul 3, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Saeed El-AshramAbeer El Wakil
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Methods Mentioned

BETA
dynamic
transmission electron microscopy
Fluorescence
biopsy
PCR
electron microscopy
Scanning Transmission Electron Microscopy

Software Mentioned

- Quest
Cell
ZEN
ImageJ
SigmaPlot
Leica Application Software X ( LAS X )

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