Tannin-mediated secretion of a neutrophil chemotactic factor from alveolar macrophages. Potential contribution to the acute pulmonary inflammatory reaction associated with byssinosis

The American Review of Respiratory Disease
M S RohrbachJ A Russell

Abstract

Inhalation of cotton mill dust or condensed tannin, a major botanical component of cotton mill dust, induces an acute pulmonary inflammatory response characterized by a rapid influx of neutrophils into the airways. The development of neutrophil alveolitis caused by tannin inhalation is accompanied by the accumulation of low molecular weight neutrophil chemotactic factor (NCF) in the airways. To determine if the alveolar macrophage is the source of this NCF, the ability of tannin to induce the secretion of NCF from rabbit alveolar macrophages was examined in vitro. Tannin did promote the secretion of NCF from alveolar macrophages in a time- and dose-dependent manner. Secretion began immediately after challenge and was maximal after 4 to 5 h. Maximal secretion occurred at a tannin concentration of 50 micrograms/ml. Comparison with the dose response for NCF secretion by cotton dust extract indicated that tannin was the major component in the dust responsible for NCF secretion from alveolar macrophages in the time period examined. The NCF had an apparent molecular weight of greater than 800 as determined by gel chromatography. The NCF could be extracted into organic solvents, suggesting it was a lipid. Its secretion, however, could...Continue Reading

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Citations

Jan 1, 1994·American Journal of Industrial Medicine·M S Rohrbach
Aug 26, 1998·Biochimica Et Biophysica Acta·N V RalstonH H Schmid
Dec 1, 1995·Journal of Toxicology and Environmental Health·S G Von EssenS I Rennard
Aug 1, 1992·American Journal of Respiratory Cell and Molecular Biology·T KreofskyM S Rohrbach
Apr 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A WarnerJ O Warner
Oct 16, 2004·Expert Review of Anti-infective Therapy·Oliver KayserAlbrecht F Kiderlen
Jun 25, 2005·Molecular Pharmacology·Katalin ErdèlyiLászló Virag
Nov 11, 1992·British Journal of Industrial Medicine·A J De LuccaA D French
Oct 1, 1991·Japanese Journal of Pharmacology·Y UshioH Abe

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