Tanshinol ameliorates CCl4 -induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway

Drug Design, Development and Therapy
Rong WangYongfang Yuan

Abstract

Tanshinol, a water-soluble component isolated from Salvia miltiorrhiza Bunge, has a variety of biological activities involving anti-fibrotic effect. However, the exact role and the underlying mechanisms remain largely unclear. This study mainly focused on the anti-hepatic fibrotic activities and mechanisms of tanshinol on carbon tetrachloride (CCl4)-induced liver fibrosis in rats via anti-oxidative and anti-inflammation pathways. The rats were divided into 4 groups as follows: control, model, tanshinol 20 mg/kg, and tanshinol 40 mg/kg. Except for the control group, CCl4 was used to induce liver fibrosis processing for 8 weeks, meanwhile rats in tanshinol groups were intraperitoneally injected with additional tanshinol. Control group simultaneously received the same volumes of olive oil and saline. The potentially protective effect and mechanisms of tanshinol on liver fibrosis in rats were evaluated. The serum levels of alanine aminotransferase, aspartate aminotransferase, and total bilirubin were obviously lower in the tanshinol treatment groups related to model group. Compared with the model group, the levels of hyaluronic acid, type IV collagen, Laminin (LN), and procollagen III peptide (PIIIP) in serum were significantly dec...Continue Reading

Citations

Sep 20, 2018·Toxicology and Industrial Health·Zulfia HussainIram Arif
Jun 12, 2019·Journal of Immunology Research·José Roberto Macías-PérezJavier Ventura-Juárez
Mar 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Md Mizanur RahmanMd Ashraful Alam
Apr 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Deqian MengKai Wang
Dec 18, 2021·Drug and Chemical Toxicology·Nayeon YangTaekyun Shin

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Methods Mentioned

BETA
electrophoresis
Fluorescence
protein assay
PCR
MDA
nuclear translocation

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