Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Jian FangPei-Qing Liu

Abstract

The adaptive changes that develop in the pressure-overloaded left ventricular myocardium include cardiac hypertrophy and interstitial fibrosis. The objectives of the present study were to evaluate the effects of Tanshinone II-A, a bioactive diterpene quinone isolated from Danshen, on cardiac fibrosis and collagen metabolism in rats with renovascular hypertension. Male Sprague-Dawley rats were subjected to two-kidney two-clip (2K2C) or sham operation (sham) and treated with Valsartan (Val, 26.7 mg/kg/d), Tanshinone II-A (Tsn, 70, 35 mg/kg/d) or vehicle. Six weeks later, systolic blood pressure (BP), LV weight, collagen abundance, cardiac function parameters, hydroxyproline content and mRNA levels of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 were evaluated. Both high-dose (Tsn-H, 70 mg/kg/d) and low-dose (Tsn-L, 35 mg/kg/d) of Tsn failed to attenuate 2K2C-induced BP elevation but significantly attenuated the attendant interstitial fibrosis. Val suppressed elevations of BP and left ventricular systolic pressure (LVSP) in 2K2C rats. Val and Tsn-H exerted comparable suppressive effects on the gene expression of MMP-9 and TIMP-1, while Val decreased the MMP-2 mRNA level without...Continue Reading

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Citations

Feb 13, 2015·Molecular Medicine Reports·Huanyu HeTaihua Wu
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Qinghua ShangLi Huang
Jul 22, 2011·Atherosclerosis·Si GaoSuowen Xu
Dec 13, 2012·Expert Opinion on Therapeutic Patents·Suowen Xu, Peiqing Liu
Jan 31, 2015·Journal of Cardiovascular Pharmacology·Fan YangLuosha Zhao
Apr 27, 2018·Acta Pharmacologica Sinica·Zhuo-Ming LiPei-Qing Liu
Feb 27, 2020·International Journal of Hypertension·Yuejia DingJunping Zhang
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhangyang BiWei Zhang
Nov 26, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhibei LiXiao Ma

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