Tantalum oxide nanoparticles as an advanced platform for cancer diagnostics: a review and perspective.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Ekaterina KoshevayaPavel Krivoshapkin

Abstract

The development of new safe and effective contrast agents (CAs) is a crucial factor to increase the effectiveness of computed tomography (CT). For now, tantalum oxide-based nanoparticles (TaOx NPs) are among the most promising CAs for CT due to their superior properties: high X-ray attenuation coefficient, excellent biocompatibility, and easily modifiable surface chemistry. Compared to the commercially available analogs (iodine-based CAs), TaOx NPs provide better contrast performance, long-circulation, and high safety profiles (reduced exposure of X-rays and CA dosage). Among the investigated nanoparticulate CAs they afford higher cost-effectiveness (Au, Pt, Lu). TaOx NPs can also be easily modified to include other imaging or therapeutic modalities. This review aims to summarize the current state-of-the-art knowledge in the field of tantalum oxide-based CAs used for single or multimodal imaging and theranostic purposes. The design specification of TaOx NPs in terms of size, surface functionalization, composition, and their influence on the contrast performance, toxicity, and pharmacokinetics are discussed. Finally, the future opportunities and challenges of TaOx NPs used as CT CAs are addressed.

References

Jan 1, 1995·Acta Radiologica. Supplementum·I F HeglundE Holtz
Dec 26, 2001·Chemical Reviews·S B Yu, A D Watson
Jun 20, 2003·The New England Journal of Medicine·Mukesh G HarisinghaniRalph Weissleder
Feb 25, 2006·The British Journal of Radiology·J F HainfeldH M Smilowitz
Oct 19, 2007·Journal of the American Society of Nephrology : JASN·Erdmann SeeligerPontus B Persson
Apr 9, 2010·Investigative Radiology·Gregor JostMartin A Sieber
Jun 1, 2010·Biomaterials·François HallouardThierry Vandamme
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Oct 27, 2010·Chemical Communications : Chem Comm·Peter J BonitatibusAmit M Kulkarni
Jan 13, 2011·The Journal of Physical Chemistry. B·Sungsook AhnSang Joon Lee
Jan 26, 2011·Nanotoxicology·Yan MaJun-Ichi Kikuchi
Jun 24, 2011·International Journal of Nanomedicine·Liuba TaccolaAlfred Cuschieri
Jan 24, 2012·European Heart Journal·Erdmann SeeligerPontus B Persson
Jul 28, 2012·Investigative Radiology·Andrew S TorresMichael E Marino
Dec 6, 2012·Chemical Reviews·Hrvoje Lusic, Mark W Grinstaff
Jan 29, 2014·Contrast Media & Molecular Imaging·David P CormodeZahi A Fayad
Apr 8, 2014·BioMed Research International·Erdmann SeeligerPontus B Persson
Jul 22, 2014·Contrast Media & Molecular Imaging·José Carlos De La Vega, Urs O Häfeli
Jan 21, 2015·Nanomedicine·Lisa E ColeRyan K Roeder
Nov 26, 2015·Radiology·Robert J McDonaldMatthew S Davenport
Mar 19, 2016·Contrast Media & Molecular Imaging·Julia G MannheimBernd J Pichler
Sep 14, 2016·Advanced Drug Delivery Reviews·Benjamin M YehPeter J Bonitatibus
Dec 12, 2018·Journal of Colloid and Interface Science·Kathrin BoguszKonstantin Konstantinov

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