Tao-1 is a negative regulator of microtubule plus-end growth.

Journal of Cell Science
Tao LiuBuzz Baum

Abstract

Microtubule dynamics are dominated by events at microtubule plus ends as they switch between discrete phases of growth and shrinkage. Through their ability to generate force and direct polar cell transport, microtubules help to organise global cell shape and polarity. Conversely, because plus-end binding proteins render the dynamic instability of individual microtubules sensitive to the local intracellular environment, cyto-architecture also affects the overall distribution of microtubules. Despite the importance of plus-end regulation for understanding microtubule cytoskeletal organisation and dynamics, little is known about the signalling mechanisms that trigger changes in their behaviour in space and time. Here, we identify a microtubule-associated kinase, Drosophila Tao-1, as an important regulator of microtubule stability, plus-end dynamics and cell shape. Active Tao-1 kinase leads to the destabilisation of microtubules. Conversely, when Tao-1 function is compromised, rates of cortical-induced microtubule catastrophe are reduced and microtubules contacting the actin cortex continue to elongate, leading to the formation of long microtubule-based protrusions. These data reveal a role for Tao-1 in controlling the dynamic inte...Continue Reading

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Oct 10, 2013·Science Signaling·Leonie Enderle, Helen McNeill
Sep 21, 2012·Journal of Cell Science·Daniel HumphreysVassilis Koronakis
Sep 7, 2011·The Journal of Cell Biology·Jennifer L RohnBuzz Baum
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Aug 28, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Xudong HuangXinhua Lin
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May 8, 2018·Acta Neuropathologica Communications·Caterina GiacominiJonathan D H Morris
Apr 20, 2021·Frontiers in Molecular Neuroscience·Chun HuLin Xiao

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