TAP and TAP-like--brothers in arms?

Naunyn-Schmiedeberg's Archives of Pharmacology
Chenguang ZhaoRupert Abele

Abstract

The transporter associated with antigen processing like (TAPL, ABCB9) is a member of the ATP-binding cassette (ABC) transporter family. Moreover, TAPL belongs to the TAP family due to its high sequence homology to TAP1 and TAP2. TAPL forms a homodimer which is localized in lysosomes with a minor fraction in the ER. It functions as an ATP-dependent peptide transporter which shows a broad peptide specificity ranging from 6-mer up to 59-mer peptides. In contrast to TAP, TAPL transports peptides with low affinity but high efficiency. This review will briefly summarize current knowledge about the structural organization and possible physiological function of TAPL in antigen processing and presentation.

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Citations

Mar 11, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Ernst PetzingerRobert Tampé
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Barbara BecattiniMaurizio Pellecchia
Jul 23, 2013·PloS One·Alexandra SimonEllen I Closs
Apr 5, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lauren E Shipp, Amro Hamdoun
Jun 3, 2017·The Journal of Biological Chemistry·Victoria FettelschossMatthias R Baumgartner
Feb 27, 2015·Biological Chemistry·Tina ZollmannRupert Abele
Apr 25, 2008·The Journal of Biological Chemistry·Chenguang ZhaoRupert Abele
Apr 23, 2020·Pharmacology & Therapeutics·Eva Gil-MartinsRenata Silva

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