TAP genes and immunity

Current Opinion in Immunology
James McCluskeyAnthony W Purcell

Abstract

The transporter associated with antigen processing (TAP) is a member of the ATP-binding cassette transporter family that specializes in delivering cytosolic peptides to class I molecules in the endoplasmic reticulum. The TAP is a major target of genetic alteration in tumours and disruption by viral inhibitors. In some species, TAP genes have co-evolved with MHC class I molecules to deliver peptides that are customised for particular alleles. In humans, MHC class I polymorphism determines the level of tapasin-mediated association with TAP and subsequent peptide optimisation within the peptide-loading complex (PLC). MHC class I molecules that still load peptides without complexing to the TAP might be more resistant to viral interference of the PLC and less sensitive to competition for TAP by other class I allotypes.

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·P M van EndertH O McDevitt
Aug 1, 1995·European Journal of Immunology·R ObstG J Hämmerling
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·T N SchumacherH L Ploegh
Jan 1, 1993·Immunogenetics·S H PowisJ Trowsdale
Dec 3, 1999·Biochimica Et Biophysica Acta·R Abele, R Tampé
Aug 10, 2000·Clinical and Experimental Immunology·S D GadolaV Cerundolo
Sep 1, 2001·Clinical and Experimental Immunology·N MatamorosM López-Botet
Feb 28, 2002·Immunogenetics·Héth R TurnquistJoyce C Solheim
Apr 6, 2002·International Immunology·Marie-Eve Paquet, David B Williams
Apr 26, 2002·Tissue Antigens·A WilliamsT Elliott
Sep 5, 2002·Genes and Immunity·G Vargas-AlarcónJ Granados
Mar 22, 2003·The Journal of Investigative Dermatology·Chul-Woo PyoTai-Gyu Kim
Mar 22, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S ZhangD-A Vuitton
Apr 19, 2003·Archives of Dermatological Research·J DissemondS N Wagner
Apr 23, 2003·Microbes and Infection·Georg LautschamNeil Blake
Jun 6, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·N DhimanG A Poland
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Angel Garcia-LoraFederico Garrido
Aug 15, 2003·World Journal of Gastroenterology : WJG·Xiao-Ling DengDa-Peng Wei
Sep 3, 2003·Virus Research·Aruna P N AmbagalaS Srikumaran
Sep 26, 2003·Nature·Mathieu HoudeMichel Desjardins
Oct 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anne L AckermanPeter Cresswell
Dec 18, 2003·The Journal of Biological Chemistry·Joachim KochRobert Tampé
Jan 22, 2004·Current Opinion in Immunology·Paul J Lehner, Peter Cresswell

❮ Previous
Next ❯

Citations

May 20, 2006·Pflügers Archiv : European journal of physiology·Meike Herget, Robert Tampé
May 13, 2006·Journal of Bioenergetics and Biomembranes·Christian Schölz, Robert Tampé
Jan 16, 2014·Indian Journal of Virology : an Official Organ of Indian Virological Society·B M PratheekSubhasis Chattopadhyay
Sep 2, 2009·Immunology and Cell Biology·Angelo TheodoratosAude M Fahrer
Jul 22, 2008·Nature Chemical Biology·Rachelle Gaudet
Jan 8, 2009·Molecular Biology and Evolution·Demetrios VassilakosA Rus Hoelzel
Jan 6, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Abigail CulshawSarah Louise Rowland-Jones
May 8, 2014·Environmental Health and Preventive Medicine·Takenori YamauchiYoshiki Kuroda
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Robert M Greenberg
Mar 18, 2008·Experimental and Molecular Pathology·Arnoldo Aquino-GalvezMoisés Selman
Apr 11, 2007·Neurobiology of Aging·María J BullidoFernando Valdivieso
May 15, 2007·Annals of the New York Academy of Sciences·Yu-Tsueng Liu, Chun-Ming Huang
May 16, 2012·European Journal of Immunology·Jacqueline AdamDaniel Yerly
Apr 6, 2006·Neurobiology of Aging·María J BullidoFernando Valdivieso
Jun 5, 2015·Breast Cancer Research : BCR·Ran RostokerDerek LeRoith
Jan 25, 2007·Pediatric Pulmonology·Deniz DoğruMeral Ozgüç
Mar 17, 2007·Genes, Chromosomes & Cancer·Akash M MehtaGert J Fleuren
Jul 8, 2005·Expert Review of Proteomics·Nicholas A Williamson, Anthony W Purcell
Nov 17, 2019·Molecular and Cellular Biochemistry·Abaineh Munshea AbitewAjay Wanchu
Nov 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helen BrosiReinhold Schirmbeck
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luc Van Kaer
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuanmei LouWilfred A Jefferies

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.