PMID: 9645419Jun 30, 1998Paper

TAP2 alleles in inflammatory arthritis

Scandinavian Journal of Rheumatology
J TuokkoJ Ilonen

Abstract

Sixty patients with reactive arthritis (ReA) and 40 with rheumatoid arthritis (RA), were typed for H LA-B27 and class II antigens DR and DQ, and studied for TAP2 gene polymorphism in comparison with 60 healthy controls. TAP2 polymorphisms at positions 379, 565, 665, and 687 were analyzed using amplification refractory system-based PCR and polymorphisms at positions 386 and 651 using oligonucleotide hybridization. The frequency of the TAP2A/A genotype was 30%(12/40) in RA, in contrast to 13% (8/60) in the controls. This genotype was further associated with DRB1*04 positive RA (10/24, 42%, P=0.01), as well as the TAP2A allele (31/48, 65%, P =0.012). Thr/Thr dimorphism at TAP2 position 665 (24/40, 60%, P=0.024) and Stop/Stop dimorphism at TAP2 position 687 (24/40, 60%, P=0.024) were found to be increased in RA patients as compared to controls. When TAP2I/J polymorphism was studied, TAP2J positivity was found associated with the HLA-B27DR4-DQB1*0301-haplotype in ReA patients. 9/12 of these were positive as compared to 20/60 in random controls (P=0.010). Polymorphisms of the TAP2 gene were found to be associated with subgroups of RA and ReA patients with disease associated markers (e.g. TAP2A in DRB1*04 positive RA, or TAP2J in HLA-...Continue Reading

References

Jul 1, 1995·Current Opinion in Rheumatology·J A López de Castro
May 1, 1995·Annals of the Rheumatic Diseases·M F González-EscribanoB Sánchez
Jul 1, 1994·Tissue Antigens·J G BodmerT Sasazuki
Apr 1, 1994·Tissue Antigens·O Olerup
Jan 1, 1993·Immunogenetics·S H PowisJ Trowsdale
Jun 1, 1994·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·R P DonnW E Ollier

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Citations

Jun 6, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S-L ZhangE Toussirot
Jan 30, 2004·Genes and Immunity·J L NewtonM A Brown
Jul 26, 2000·Current Opinion in Rheumatology·A Toivanen, P Toivanen
Mar 7, 2001·Arthritis and Rheumatism·J TuokkoJ Ilonen

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