TAp63gamma is required for the late stages of myogenesis

Cell Cycle
S CefalùE Candi

Abstract

p53 family members, p63 and p73, play a role in controlling early stage of myogenic differentiation. We demonstrated that TAp63gamma, unlike the other p53 family members, is markedly up-regulated during myogenic differentiation in murine C2C7 cell line. We also found that myotubes formation was inhibited upon TAp63gamma knock-down, as also indicated by atrophyic myotubes and reduction of myoblasts fusion index. Analysis of TAp63gamma-dependend transcripts identified several target genes involved in skeletal muscle contractility energy metabolism, myogenesis and skeletal muscle autocrine signaling. These results indicate that TAp63gamma is a late marker of myogenic differentiation and, by controlling different sub-sets of target genes, it possibly contributes to muscle growth, remodeling, functional differentiation and tissue homeostasis.

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Citations

Feb 19, 2020·Clinical Genetics·Stine W MathorneChristina R Fagerberg
Nov 30, 2018·Aging·Veronica CiuffoliEleonora Candi
Sep 13, 2020·Journal of Cell Science·Matthew L FisherAlea A Mills
Nov 6, 2017·Cellular and Molecular Life Sciences : CMLS·Eduardo Soares, Huiqing Zhou
Oct 5, 2018·Frontiers in Physiology·Wen LuoXiquan Zhang
Apr 4, 2020·The Journal of Investigative Dermatology·Shakur MohibiXinbin Chen
Feb 7, 2021·FEBS Open Bio·Xueying FanChenghua Li
Feb 28, 2021·The Journal of Pathology·Zuzana PokornáPhilip J Coates
Oct 12, 2021·European Journal of Human Genetics : EJHG·Julia SchmidtBernd Wollnik

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Methods Mentioned

BETA
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Software Mentioned

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