Taq I polymorphism of the vitamin D receptor and risk of severe diabetic retinopathy

Diabetologia
Mariano J TavernaJ-L Selam

Abstract

Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. 200 unrelated C-peptide-negative French Type I diabetic patients were randomly selected (male:female, 103:97, age 44.4 +/- 12.4 years, diabetes duration: 27.7 +/- 10.0 years, BMI: 24.3 +/- 3.4 kg/m(2), HbA(1c): 8.6 +/- 1.3 %). The Taq I site was analysed by PCR followed by digestion with Taq I enzyme. Diabetic retinopathy was assessed by retinal angiography and classified as presence (n = 101) or absence (n = 99) of severe (preproliferative or proliferative) diabetic retinopathy. Frequency of wild-type genotype TT was lower in patients with severe diabetic retinopathy (n = 27) when compared with control subjects (n = 42, OR = 0.5, p = 0.028). Allele frequencies were not different between patients (T: n = 112 and t: n = 90) and control subjects (T: n = 128, and t: n = 70, p = 0.075). Global chi(2) (df = 2): p = 0.064. In subjects with diabetes duration of more than 25 years, TT was lower in severe diabetic retinopathy (n = 14) than...Continue Reading

Citations

Oct 25, 2002·Diabetes/metabolism Research and Reviews
Jan 30, 2013·Clinical Reviews in Allergy & Immunology·Chen-Yen YangM Eric Gershwin
Apr 27, 2012·Genetics and Molecular Research : GMR·H C Vural, E Maltas
Feb 18, 2016·Journal of Diabetes Research·Uazman AlamRayaz A Malik
Jun 6, 2007·Medical Hypotheses·Allam Appa RaoUndurti N Das
Apr 27, 2005·Diabetes/metabolism Research and Reviews·Khanh vinh quoc LuongDung Ngoc Pham Nguyen
Nov 26, 2015·Eye and Vision·Ryan LeeCharumathi Sabanayagam
Sep 5, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·R HeW Jia
Oct 8, 2014·Diabetes Research and Clinical Practice·Naoki ShimoMunehide Matsuhisa
Mar 1, 2015·Experimental Eye Research·Rose Y Reins, Alison M McDermott
Apr 21, 2017·Genes·Marissa Penna-Martinez, Klaus Badenhoop
Jan 8, 2017·Reviews in Endocrine & Metabolic Disorders·M GrammatikiKalliopi Kotsa
Mar 6, 2016·The Journal of International Medical Research·Xiaoyan XiaoZhao Hu
Aug 27, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anita BarišićBorut Peterlin
Jun 23, 2010·Ophthalmic Genetics·Javad Tavakkoly BazzazIan V Hutchinson
Jul 1, 2010·Personalized Medicine·Timothy Yy LaiChi Pui Pang
Apr 25, 2020·International Journal of Molecular Sciences·Pei-Li YaoGoldis Malek
Sep 12, 2020·Antioxidants·Patricia Fernandez-RobredoAlfredo Garcia-Layana
Jun 11, 2020·Archives of Dermatological Research·Lillian SunMelissa Piliang
Sep 27, 2018·Hormones : International Journal of Endocrinology and Metabolism·Maria GrammatikiKalliopi Kotsa

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