Taraxasterol inhibits IL-1β-induced inflammatory response in human osteoarthritic chondrocytes

European Journal of Pharmacology
Taikui PiaoJianyu Liu

Abstract

Osteoarthritis (OA), a chronic degenerative joint disease, is a leading cause of disability among elderly patients. Taraxasterol, a pentacyclic-triterpene isolated from Taraxacum officinale, has been shown to have anti-inflammatory effects. However, the protective effect of taraxasterol on OA remains unclear. In order to provide a scientific basis for the applicability of taraxasterol in OA, the anti-inflammatory effects of taraxasterol on IL-1β-stimulated osteoarthritic chondrocytes were investigated. Chondrocytes were pretreated with taraxasterol 1h before IL-1β treatment. The productions of MMP-1, MMP3, MMP13, PGE2 and NO were measured by ELISA and Griess reaction. The expression of COX-2, iNOS, and NF-κB was detected by western blot analysis. Our results demonstrated that taraxasterol dose-dependently suppressed MMP-1, MMP3, MMP13, PGE2 and NO production induced by IL-1β. The expression of COX-2 and iNOS was also inhibited by taraxasterol. Western blot analysis showed that taraxasterol suppressed IL-1β-induced NF-κB activation in a dose-dependent manner. Taken together, we found that taraxasterol protected human chondrocytes by inhibiting MMPs, NO and PGE2 production. Taraxasterol may be a useful agent for prevention and tr...Continue Reading

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Citations

Apr 26, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Huaqi TangYikun Sun
Apr 26, 2016·Journal of Ethnopharmacology·Shasha WangXuemei Zhang
Mar 11, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Dong-Geun KangJin Sung Park
Jan 10, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ho Jong RaSun-Chul Hwang
Jan 16, 2018·Pharmacognosy Research·Francisco Alcione Nobre da SilvaAntonio Carlos Romão Borges
Oct 3, 2018·Journal of Cellular Biochemistry·Yuan Zhang, Qing Zhao
Sep 22, 2020·World Journal of Gastroenterology : WJG·Ronald Neil KostoffDarla Roye Shores
Jan 20, 2017·Experimental and Therapeutic Medicine·Shu-Hua JiangZhi-Juan Sun

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