Taraxerone enhances alcohol oxidation via increases of alcohol dehyderogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities and gene expressions

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Chang-Keun SungEun-Kyoung Mo

Abstract

The present study, taraxerone (d-friedoolean-14-en-3-one) was isolated from Sedum sarmentosum with purity 96.383%, and its enhancing effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were determined: EC(50) values were 512.42 ± 3.12 and 500.16 ± 3.23 μM for ADH and ALDH, respectively. In order to obtain more information on taraxerone related with the alcohol metabolism, 40% ethanol (5 mL/kg body weight) with 0.5-1mM of taraxerone were administered to mice. The plasma alcohol and acetaldehyde concentrations of taraxerone-treated groups were significantly lowered than those of the control group (p<0.01): approximately 20-67% and 7-57% lowered for plasma alcohol and acetaldehyde, respectively. Compare to the control group, the ADH and ALDH expressions in the liver tissues were abruptly increased in the taraxerone-treated groups after ethanol exposure. In addition, taraxerone prevented catalase, superoxide dismutase, and reduced glutathione concentrations from the decrease induced by ethanol administration with the concentration dependent manner.

References

Oct 24, 1977·Biochemical and Biophysical Research Communications·A I CederbaumG Cohen
Mar 23, 2000·Fitoterapia·W N SetzerR O Lawton
Nov 18, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hu-Quan YinByung-Hoon Lee
Jan 10, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tilak KhanalHye Gwang Jeong
Nov 26, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yunus AhmedM A Sattar
Feb 9, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bae-Jin LeeJae-Young Je
Oct 25, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Guilan LiLan Luo
Nov 8, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu YanChun-Fu Wu
Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yi ShenJing Liang

❮ Previous
Next ❯

Citations

Apr 5, 2016·International Journal of Environmental Research and Public Health·Yu-Jie ZhangHua-Bin Li
May 15, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xu ChenLingyuan Xu
Sep 30, 2016·International Journal of Molecular Sciences·Yu-Jie ZhangHua-Bin Li
Feb 27, 2015·World Journal of Biological Chemistry·Ji Yeon KimWon-Ho Kim
Apr 9, 2020·Alcoholism, Clinical and Experimental Research·Joshua SilvaJing Liang
Oct 20, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jing LuYingjian Lu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.