PMID: 220654Mar 22, 1979

Tardive dyskinesia: a clinical test of the supersensitivity hypothesis

M B BowersD Tarsy


Patients with tardive dyskinesia showed no significant difference in CSF HVA when compared with groups of schizophrenic or depressives. CSF cAMP in the tardive dyskinesia group was significantly lower when compared to schizophrenics but not depressives. These results do not support a dopamine-receptor supersensitivity hypothesis in permanent tardive dyskinesia.


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