Target-controlled propofol infusion during monitored anesthesia in patients undergoing ERCP

Gastrointestinal Endoscopy
L FantiP A Testoni

Abstract

A target-controlled infusion system automatically adjusts the rate of infusion of propofol to maintain a desired (target) concentration. The aim of this study was to determine whether administration of propofol with a target-controlled infusion system could improve the sedation of patients undergoing ERCP. A total of 205 consecutive patients undergoing ERCP were sedated by using a propofol target-controlled infusion system by an anesthesiologist. The target plasma concentration of propofol ranged from 2 to 5 microg/mL. A bolus dose of fentanyl (50-100 mcg) was administered if signs of insufficient analgesia were observed at the maximum target concentration of propofol allowed. The technical difficulty of ERCP was graded on a scale from 1 (least difficult) to 5 (most difficult). The mean dosages of propofol and fentanyl administered were 465 (245) mg and 59 (23) mcg, respectively. The total dose of propofol administered and the mean duration of ERCP were related to the degree of difficulty of the procedure. No severe complication was observed; mean time to discharge was 31 (12) minutes. Time to discharge was not influenced by the difficulty of ERCP or by the total dose of propofol administered. A target-controlled infusion syste...Continue Reading

Associated Clinical Trials

Jan 6, 2014·Byung Hyo Cha, MD, Byung Hyo Cha, MD

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Citations

Jul 11, 2006·Journal of Clinical Gastroenterology·Ronnie Fass, Ram Dickman
May 27, 2010·World Journal of Gastroenterology : WJG·Lorella Fanti, Pier-Alberto Testoni
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