Target delineation variability and corresponding margins of peripheral early stage NSCLC treated with stereotactic body radiotherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Heike PeulenJan-Jakob Sonke

Abstract

To quantify the target delineation variability in peripheral early stage lung cancer treated with SBRT and derive corresponding margins. Sixteen early stage NSCLC GTV's were delineated by 11 radiation oncologists from 4 institutes. A median surface was computed and the delineation variation perpendicular to this surface was measured (local standard deviation=SD). The overall target delineation variability was quantified by the root-mean-square (rms) of the local SD. The required margin was determined by expanding all delineations to encompass the median surface, where after the underlying probability distribution was modeled by a number of uncorrelated 'pimples-and-dimples'. The overall target delineation variability was 2.1mm (rms). Institute I-III delineated significantly smaller volumes than institute IV, yielding target delineation variabilities of 1.2mm and 1.8mm respectively. The margin required to obtain 90% coverage of the delineated contours was 3.4mm and 5.9mm respectively. The factor α in M=αΣ required to calculate adequate margins was 2.8-3.2, which is larger than the 2.5 found for 3D rigid target displacement. A relatively small target delineation uncertainty of 1.2mm-1.8mm (1SD) was observed for early stage NSCLC....Continue Reading

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Citations

Oct 13, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shalini K VinodLois C Holloway
Dec 3, 2020·Physics in Medicine and Biology·Vincent CailletPaul Keall
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Jun 28, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Kristin KarlssonGavin Poludniowski

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