Target delivery of doxorubicin tethered with PVP stabilized gold nanoparticles for effective treatment of lung cancer

Scientific Reports
Vaikundamoorthy RamalingamRajendran Rajaram

Abstract

Development of drug delivery system conjugated with doxorubicin (dox) on the surface of AuNPs with polyvinylpyrrolidone (Dox@PVP-AuNPs), we have demonstrated that human lung cancer cells can significantly overcome by the combination of highly effective cellular entry and responsive intracellular release of doxorubicin from Dox@PVP-AuNPs complex. Previously drug release from doxorubicin-conjugated AuNPs was confirmed by the recovered fluorescence of doxorubicin from quenching due to the nanosurface energy transfer between doxorubicinyl groups and AuNPs. Dox@PVP-AuNPs achieved enhanced inhibition of lung cancer cells growth than free Doxorubicin and PVP-AuNPs. The in vitro cytotoxic effect of PVP-AuNPs, free Dox and Dox@PVP-AuNPs inhibited the proliferation of human lung cancer cells with IC50 concentration. Compared with control cells, PVP-AuNPs and free Dox, Dox@PVP-AuNPs can increases ROS generation, sensitize mitochondrial membrane potential and induces both early and late apoptosis in lung cancer cells. Moreover, Dox@PVP-AuNPs highly upregulates the expression of tumor suppressor genes than free Dox and PVP-AuNPs and induces intrinsic apoptosis in lung cancer cells. From the results, Dox@PVP-AuNPs can be considered as an pot...Continue Reading

References

May 26, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Helene PelicanoPeng Huang
Dec 22, 2007·Nature Reviews. Molecular Cell Biology·Richard J Youle, Andreas Strasser
Apr 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yong-Jig Cho, Peng Liang
Sep 2, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiromasa YamamotoTetsuya Mitsudomi
Nov 20, 2009·Nanotechnology·Min ZhouSteinar Raaen
Dec 2, 2009·Methods in Molecular Biology·Jean-Pierre Gillet, Michael M Gottesman
Apr 8, 2010·Free Radical Research·Geou-Yarh Liou, Peter Storz
Feb 1, 2011·The Lancet Oncology·William Pao, Nicolas Girard
Sep 6, 2011·Annual Review of Medicine·Andrew Z WangOmid C Farokhzad
May 15, 2012·Advanced Drug Delivery Reviews·P Couvreur
Nov 24, 2012·Nature Reviews. Molecular Cell Biology·Lorenzo GalluzziGuido Kroemer
Jan 29, 2013·Journal of Colloid and Interface Science·Jean-Claude TinguelyJoachim R Krenn
Feb 21, 2013·International Journal of Medical Sciences·Alberto AntonicelliAndré Emanuel Dutly
Jun 5, 2013·Cold Spring Harbor Perspectives in Biology·Amanda B ParrishSally Kornbluth
Oct 22, 2013·Cell Death and Differentiation·S KookE V Gurevich
Dec 19, 2013·Genes & Cancer·Vincent Picco, Gilles Pagès
Mar 4, 2014·Cell Death and Differentiation·M OgruncF d'Adda di Fagagna
Oct 7, 2014·Chemical Communications : Chem Comm·Christophe DeraedtDidier Astruc
Feb 11, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Selvaraju KarthikVilwanathan Ravikumar
Apr 17, 2015·Current Topics in Medicinal Chemistry·Daniela CabuzuAlexandru Mihai Grumezescu
Sep 20, 2015·Nucleic Acids Research·Martin FischerKurt Engeland
Dec 3, 2015·Nature Communications·Yue LuZhen Gu
Feb 8, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ramalingam VaikundamoorthyRajaram Rajendran
Feb 16, 2016·Scientific Reports·Alexandra RodzinskiSakhrat Khizroev
Nov 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Eun Young KimDong-Kwon Lim

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Citations

Feb 29, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Vaikundamoorthy RamalingamMohan Harshavardhan
Jul 11, 2018·International Journal of Molecular Sciences·Priyanka SinghIvan Mijakovic
Oct 5, 2018·Applied Biochemistry and Biotechnology·Agnieszka Małgorzata PudlarzJanusz Szemraj
May 1, 2019·Cancers·Anubhab MukherjeeSudip Mukherjee
Mar 1, 2019·International Journal of Molecular Sciences·Safia NazJinghua Chen
Mar 17, 2020·Drug Delivery and Translational Research·Arpit BhargavaPradyumna Kumar Mishra
May 18, 2020·Polymers·Paola Franco, Iolanda De Marco
Nov 3, 2020·Drug Development Research·Parteek PrasherSamarth Pratap Singh
Jun 23, 2020·Colloids and Surfaces. B, Biointerfaces·Kai S Exner, Anela Ivanova
Nov 22, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mara GonçalvesHelena Tomás
Jan 29, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irena MaliszewskaKatarzyna Matczyszyn
Nov 12, 2020·Advanced Therapeutics·Joydeb Majumder, Tamara Minko
Jan 27, 2021·ACS Nano·Joshua SeabergPriyabrata Mukherjee
Mar 4, 2021·Journal of Nanoscience and Nanotechnology·Rossana TerraccianoGuido Pagana
Mar 6, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Nandan Gupta, Rishabha Malviya
Mar 7, 2021·International Journal of Molecular Sciences·Gyeongyun GoSang Hun Lee
May 3, 2021·International Journal of Pharmaceutics·Adewale O OladipoTitus A M Msagati
Jun 22, 2021·Seminars in Cancer Biology·Serenella MediciMaria Antonietta Zoroddu
Jun 24, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bicong ZhouChangmin Yu
Aug 11, 2021·Advanced Drug Delivery Reviews·Rajeswari RaguramanRajagopal Ramesh
Jan 31, 2019·Molecular Pharmaceutics·Fakhrossadat EmamiSimmyung Yook
Sep 23, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weiping ZhengXin Zhan

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Methods Mentioned

BETA
surface plasmon resonance
NMR
fluorescence microscopy
flow cytometry
enzymatic assay
transmission
electron diffraction
X-ray
dynamic light scattering
enzyme-linked immunosorbent assay

Software Mentioned

FlowJo

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