Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer

Cancer Treatment Reviews
Anastasia MalekOleg Tchernitsa

Abstract

Gene expression profiling studies and conventional approaches for the identification of genes involved in the initiation and progression of ovarian cancer have identified a plethora of potential therapeutic targets. This review summarizes the targets that show promise for specific interference in cancer cells, groups them according to their subcellular localization and involved biological processes and discusses their impact on experimental, pre-clinical and clinical therapy.

References

Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S T MalikF R Balkwill
May 12, 1995·The Journal of Biological Chemistry·W H Herman, M S Simonson
Feb 1, 1997·Gynecologic Oncology·S D WorsleyB R Davies
Aug 22, 1997·International Journal of Cancer. Journal International Du Cancer·V MasciulloS Mancuso
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·C MitsuokaR Kannagi
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·N AuerspergC D Roskelley
Jun 8, 2001·Journal of the Society for Gynecologic Investigation·T SawasakiK Ohama
Jul 17, 2001·Cancer Genetics and Cytogenetics·J TapperS Knuutila
Jun 19, 2002·Biochimica Et Biophysica Acta·Xianjun FangGordon B Mills
Aug 24, 2002·Clinical Science·Laura RosanòAnna Bagnato
Jan 31, 2003·Molecular Carcinogenesis·Amir A JazaeriEdison T Liu
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Mika SuzukiToshihiko Terao
Mar 19, 2003·Cancer Biology & Therapy·Adrienne D Cox, Channing J Der
Apr 16, 2003·Gynecologic Oncology·A M OzaUNKNOWN NCIC Clinical Trials Group Study (NCIC IND.116)
Jun 5, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gülsüm Ozlem ElpekNazif Hikmet Aksoy
Jun 17, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cynthia CohenRobert Santoianni
Sep 10, 2003·Molecular Biology of the Cell·Marci E SchanerBranimir I Sikic
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Aniruddha ChoudhuryRolf Kiessling
Dec 17, 2003·The Journal of Biological Chemistry·Armin RumpAtsushi Miyajima
Jan 7, 2004·Journal of the Society for Gynecologic Investigation·Johnathan M LancasterAndrew Berchuck
Feb 7, 2004·Molecular & Cellular Proteomics : MCP·Ian J Jacobs, Usha Menon
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sachin M ApteIsaiah J Fidler
Feb 27, 2004·Gynecologic Oncology·H J G ArtsE G E de Vries
May 1, 2004·American Journal of Obstetrics and Gynecology·Anil K SoodMary J C Hendrix
May 1, 2004·American Journal of Obstetrics and Gynecology·Andrew BerchuckJeffrey R Marks

❮ Previous
Next ❯

Citations

Apr 9, 2010·BMC Cancer·Yuanzheng HeS Stoney Simons
May 29, 2014·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Ruth E C EvansAlice E Simon

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Cycle Control & Proteolysis

Key regulators of cell cycle, including cyclins, cyclin dependent kinase inhibitors, DNA replication factors, are controlled by proteolysis. Discover the latest research on cell cycle control and proteolysis.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.