PMID: 7015330Feb 1, 1981Paper

Target neuron-specific process formation by embryonic mesencephalic dopamine neurons in vitro

Proceedings of the National Academy of Sciences of the United States of America
L M HemmendingerA Heller

Abstract

Mesencephalic dopamine neurons from the embryonic mouse brain were dissociated, aggregated in vitro in the presence of dissociated cells from appropriate or inappropriate target neuron areas, and visualized by the Falck-Hillarp histofluorescence technique after exposure to 1 microM exogenous dopamine. When aggregated with the surrounding rostral mesencephalic tegmentum cells only or with the addition of rostral tectum cells, the dopamine neurons formed a dense dendritic arborization, but no axons were observed. In the presence of dopamine-neuron target cells from the corpus striatum, a dense axonal plexus characteristic of that formed in this area in vivo was observed. In contrast, in aggregates formed with target cells from the frontal cortex, branching fluorescent axons bearing irregularly spaced and shaped varicosities were found coursing through the neuropil, as is characteristic of the dopaminergic innervation to the frontal cortex in vivo. Only proximal dendrites were observed in the presence of these axonal target cells. Dopamine neurons cultured with inappropriate target cells from the occipital cortex did not form either extensive axonal or dendritic processes. Thus, the presence, type, and distribution of dopamine neu...Continue Reading

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Citations

Jun 15, 1996·Journal of Neuroscience Research·E AronicaA Snyder-Keller
Sep 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·G K WenningC D Marsden
Sep 7, 2004·Cell and Tissue Research·Robert E Burke
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·P M CarveyJ Z Fields
Aug 1, 1988·Journal of Neuroscience Methods·A HellerB Heller
Jan 1, 1986·Brain Research·C B Jaeger
May 1, 1989·Brain Research. Developmental Brain Research·L WonP C Hoffmann
Jul 1, 1990·Brain Research. Developmental Brain Research·M E EhrlichP Greengard
Oct 24, 1985·Neuroscience Letters·P BrundinA Björklund
Jun 1, 1989·Brain Research Bulletin·C JaegerR Llinás
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Sep 15, 2001·Brain Research. Developmental Brain Research·A HellerL Won
Aug 14, 1999·Brain Research. Brain Research Protocols·A Barnea, J Roberts
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J A GiraultP Greengard
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H K ChoiA Heller
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·A MacayaR E Burke
Mar 1, 1983·The Journal of Cell Biology·P LiesiA Vaheri
May 28, 2004·The Journal of Comparative Neurology·C Mikaela D BerglundMats A A Persson

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