Target organ damage and incident type 2 diabetes mellitus: the Strong Heart Study

Cardiovascular Diabetology
Giovanni de SimoneRichard B Devereux

Abstract

Recent analyses in a registry of hypertensive patients suggested that preceding left ventricular (LV) hypertrophy (LVH) and/or carotid atherosclerosis are associated with incident type 2 diabetes, independent of confounders. We assess the relation between prevalent cardio-renal target organ damage (TOD) and subsequent incident type 2 diabetes in a population-based study with high prevalence of obesity. We selected 2887 non-diabetic participants from two cohorts of the Strong Heart Study (SHS). Clinical exam, laboratory tests and echocardiograms were performed. Adjudicated TODs were LVH, left atrium (LA) dilatation, and high urine albumin/creatinine ratio (UACR). Multivariable logistic regression models were used to identify variables responsible for the association between initial TODs and incident diabetes at 4-year follow-up (FU). After 4 years, 297 new cases of diabetes (10%) were identified, 216 of whom exhibited baseline impaired fasting glucose (IFG, 73%, p < 0.0001). Participants developing type 2 diabetes exhibited higher inflammatory markers, fat-free mass and adipose mass and higher prevalence of initial LVH and LA dilatation than those without (both p < 0.04). In multivariable logistic regression, controlling for age...Continue Reading

Associated Clinical Trials

May 26, 2000

References

Feb 1, 1991·Annals of Internal Medicine·G de SimoneJ H Laragh
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
May 29, 1999·Statistical Methods in Medical Research·J Barnard, X L Meng
Apr 30, 2003·Diabetes·Charles M AlexanderUNKNOWN National Cholesterol Education Program (NCEP)
Feb 16, 2005·Human Heredity·Lyle G BestJean W Maccluer
Mar 9, 2005·American Journal of Hypertension·Giovanni de SimoneUNKNOWN Strong Heart Study Investigators
Dec 29, 2005·Hypertension·Giovanni de SimoneUNKNOWN Strong Heart Study Investigators
Jan 31, 2006·Diabetes Care·Barbara V HowardRichard B Devereux
Jun 6, 2006·Journal of the American College of Cardiology·Marcello ChinaliRichard B Devereux
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Dec 29, 2006·Diabetes Care·UNKNOWN American Diabetes Association
Nov 30, 2007·The Journal of Clinical Hypertension·Dimitris P Papadopoulos, Thomas K Makris
May 17, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G de SimoneR B Devereux
Sep 24, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G de SimoneB V Howard
Oct 16, 2012·International Journal of Cardiology·Giovanni de SimoneRichard B Devereux
Jun 8, 2013·Journal of the American Heart Association·Giovanni de SimoneMary J Roman
Jul 25, 2013·European Heart Journal·Raffaele IzzoBruno Trimarco
Dec 24, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L A FerraraG de Simone
Oct 3, 2015·Cardiovascular Diabetology·Manuel Ángel Gómez-MarcosUNKNOWN LOD-DIABETES Group
Apr 2, 2016·Journal of Hypertension·Tatiana KuznetsovaUNKNOWN European Project On Genes in Hypertension (EPOGH) Investigators
Jan 5, 2017·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Grazia CancielloMaria-Angela Losi
Mar 10, 2017·Journal of the American Heart Association·Mai Tone LønnebakkenGiovanni de Simone

❮ Previous
Next ❯

Citations

May 12, 2019·Cardiovascular Diabetology·Michaela KozakovaCarlo Palombo
Aug 8, 2020·Expert Review of Cardiovascular Therapy·Sahrai SaeedPeter M Nilsson
Sep 24, 2020·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Costantino MancusiCarmine Morisco
Dec 1, 2019·Journal of Clinical Medicine·Laura Pletsch-BorbaTilman Kühn
Sep 10, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Wanlu SuYiming Mu
Nov 9, 2019·Nature Medicine·Eva Gerdts, Vera Regitz-Zagrosek

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.