Target-specific anti-fungal discovery by targeting Geotrichum candidum histidinol dehydrogenase: a hybrid approach

Chemical Biology & Drug Design
Sonia PahwaNilanjan Roy

Abstract

This study describes a hybrid approach of screening substrate analogue inhibitors of histidinol dehydrogenase. Imidazole derivative library of approximately 400 compounds classified using Hierarchical cluster analysis, representative compounds of each class were tested in enzymatic assay and used for the development of quantitative structure-activity relationship models. Rest of the compounds in the library were screened using developed models and compounds predicted active were retested. 60% of the predicted compounds showed enzyme inhibition activity with IC(50) values ranged between 5.2 and 58.0 microm range and have fungistatic activity.

References

Jan 1, 1988·Annual Review of Biochemistry·G M Kishore, D M Shah
Jul 1, 1988·Mycoses·V Buchta, M Otcenásek
Sep 1, 1987·Journal of Clinical Microbiology·H KassamaliG P Bodey
Jul 1, 1981·Human Pathology·J JagirdarE J Bottone
Jan 19, 2000·Pharmaceutical Science & Technology Today·I GroverI Bakshi
May 17, 2001·Bioorganic & Medicinal Chemistry Letters·S NarayananR Jain
May 18, 2005·Journal of Molecular Graphics & Modelling·Linnan He, Peter C Jurs
Dec 17, 2005·European Journal of Medicinal Chemistry·Rakesh Kumar TiwariAkhilesh Kumar Verma

❮ Previous
Next ❯

Citations

May 22, 2010·Bioorganic & Medicinal Chemistry Letters·Sonia PahwaNilanjan Roy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.