Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among patients with chronic headache: a secondary analysis of a randomized trial

Pain
Christopher E RamsdenJ Douglas Mann

Abstract

Omega-3 and omega-6 fatty acids are precursors of bioactive lipid mediators posited to modulate both physical pain and psychological distress. In a randomized trial of 67 subjects with severe headaches, we recently demonstrated that targeted dietary manipulation-increasing omega-3 fatty acids with concurrent reduction in omega-6 linoleic acid (the H3-L6 intervention)-produced major reductions in headache compared with an omega-6 lowering (L6) intervention. Because chronic pain is often accompanied by psychological distress and impaired health-related quality of life (HRQOL), we used data from this trial to examine whether the H3-L6 intervention favorably impacted these domains. Additionally, we examined the effect of the interventions on the number of cases with substantial physical or mental impairments as defined by cutoff values in the Brief Symptom Inventory (BSI-18), Medical Outcomes Study Short Forms 12 (SF-12), Headache Impact Test (HIT-6), and the number of headache days per month. In the intention-to-treat analysis, participants in the H3-L6 group experienced statistically significant reductions in psychological distress (BSI-18 mean difference: -6.56; 95% confidence interval [CI]: -11.43 to -1.69) and improvements in ...Continue Reading

Associated Clinical Trials

Sep 5, 2017·Kimbra Kenney

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Citations

May 11, 2015·The Journal of Pain : Official Journal of the American Pain Society·Christopher E RamsdenJoseph R Hibbeln
May 20, 2015·BMC Medicine·J Thomas BrennaAndré Briend
Jun 11, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ameer Y TahaChristopher E Ramsden
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Oct 9, 2020·The Journal of Pain : Official Journal of the American Pain Society·Anthony F DomenichielloChristopher E Ramsden
Jan 2, 2021·NPJ Science of Food·Ameer Y Taha

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