Targeted and combination treatments for vitiligo. Comparative evaluation of different current modalities in 458 subjects

Dermatologic Therapy
Torello LottiJana Hercogovà

Abstract

The current treatment of vitiligo is not satisfactory according to the opinions of both the patient population and the dermatologists. Recently, combination therapies have been introduced, which are both systemic and targeted (microphototherapy). To evaluate the effects of topical treatments given alone or in combination with 311-nm narrow-band microphototherapy. We evaluated the efficacy and safety of: (1) 311-nm narrow-band microphototherapy;(2) tacrolimus 0.1% ointment twice a day; (3) pimecrolimus 1% cream twice a day; (4) betamethasone dipropionate 0.05% cream twice a day; (5) calcipotriol ointment 50 microg/g twice a day; and (6) 10%l-phenylalanine cream twice a day, for the treatment of exclusively vitiligo patches. A 311-nm narrow-band microphototherapy (Bioskin) was given alone or in combination with the above-mentioned popular local treatments. Four hundred and seventy patients suffering from vitiligo that affected less than 10% of the skin surface were evaluated. The patients were divided into 11 groups according to the selected treatment modalities. Four hundred and fifty-eight patients completed the study period of 6 months. Excellent repigmentation (> 75%) was achieved by 72% of the patients in group 1, 76.5% in g...Continue Reading

Associated Clinical Trials

References

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Citations

Dec 2, 2008·Pigment Cell & Melanoma Research·Rafael Falabella, Maria I Barona
Oct 11, 2011·Pigment Cell & Melanoma Research·Nanja van GeelLieve Brochez
Jan 1, 2009·Clinical, Cosmetic and Investigational Dermatology·Alicia Cecile BorderéNanny van Geel
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Dec 19, 2012·Dermatologic Therapy·Brian W LeeTorello M Lotti
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