Targeted and controlled drug delivery by multifunctional mesoporous silica nanoparticles with internal fluorescent conjugates and external polydopamine and graphene oxide layers

Acta Biomaterialia
Anh-Vy TranSang-Wha Lee

Abstract

This study demonstrated the targeted delivery and controlled release of cisplatin drug molecules from doubly decorated mesoporous silica nanoparticles (MSNs), which were internally grafted with fluorescent conjugates and externally coated with polydopamine (PDA) and graphene oxide (GO) layers. The brush-like internal conjugates conferred fluorescent functionality and high capacity of cisplatin loading into MSNs, as well as contributing to a sustained release of the cisplatin through a porous channel with the assistance of external PDA layer. A consolidated double-layer formed by electrostatic interactions between the GO nanosheet and the PDA layer induced more controlled release kinetics which was well predicted by Higuchi model. In addition, Our MSNs exhibited stimuli (pH, NIR irradiation)-responsive controlled release as a potential chemo-photothermal agent against cancer cells. In a cell test, multifunctional MSNs showed a low toxicity itself, but gave a high cytotoxicity against human epithelial neuroblastoma cells (SH-SY5Y) after loading cisplatin. Notably, GO-wrapped MSNs exhibited very effective drug delivery because GO wrapping enhanced their dispensability in aqueous solution, photothermal heating effect, and efficient...Continue Reading

Citations

Mar 7, 2019·Biomaterials Science·Rushikesh S Ambekar, Balasubramanian Kandasubramanian
Feb 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Eun-Bi LimSang-Wha Lee
Jul 15, 2020·Nanomaterials·Thang Phan Nguyen, Il Tae Kim
Dec 15, 2019·Nanomaterials·Daniela Plachá, Josef Jampilek
Sep 3, 2020·International Journal of Molecular Sciences·Horrick Sharma, Somrita Mondal
Nov 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mario A TanSeong Soo A An
Jan 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chang DuChang-Ming Dong
Jan 3, 2021·Colloids and Surfaces. B, Biointerfaces·Hanmei LiQiang Peng
Mar 28, 2021·Environmental Science and Pollution Research International·Van-Dat DoanVan Thuan Le
Jun 9, 2021·Chemical Society Reviews·Peng YangYiwen Li
Jan 14, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuangling WangMeng Li

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