Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond

World Journal of Gastroenterology : WJG
M Kudo

Abstract

Systemic therapy for hepatocellular carcinoma (HCC) has markedly advanced since the survival benefit of a molecular targeted agent, sorafenib, were demonstrated in the SHARP and Asia Pacific trials in 2007. Treatment options for patients with advanced HCC increased by sorafenib, and long-term survival for patients with advanced stage HCC has become possible to some extent. However, development of a more potent first-line novel molecular targeted agent replacing sorafenib and a potent second-line agent after disease progression on or intolerant to sorafenib has been warranted because sorafenib lacks tumor shrinking/necrotizing effects and induces relatively severe adverse events such as hand foot skin reaction. Many agents in the 1st line and 2nd line setting were attempted to develop between 2007 and 2016, but all of these clinical trials failed. On the other hand, clinical trials of 4 agents (regorafenib, lenvatinib, cabozantinib, and ramucirumab) succeeded in succession in 2017 and 2018, and their use in clinical practice is possible (regorafenib and lenvatinib) or underway (cabozantinib and ramucirumab). Furthermore, all of 5 clinical trials of combination therapy with transcatheter chemoembolization (TACE) plus a molecular ...Continue Reading

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Citations

Oct 15, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hansen DangMindie H Nguyen
Jul 25, 2020·The British Journal of Radiology·Thomas Helmberger
Sep 2, 2020·Journal for Immunotherapy of Cancer·Petros FessasDavid J Pinato
Oct 4, 2020·European Radiology·Luc Defreyne
Jun 27, 2019·World Journal of Gastroenterology : WJG·Shun-Zhen ZhengJun Liu
Dec 4, 2019·Frontiers in Immunology·Meijuan Zheng, Zhigang Tian
Nov 7, 2019·Journal of Experimental & Clinical Cancer Research : CR·Ziyu LiuJiazhou Ye
May 31, 2019·Journal of Hematology & Oncology·Eishiro Mizukoshi, Shuichi Kaneko
Oct 2, 2019·International Journal of Molecular Sciences·Hendrik Reynaert, Isabelle Colle
May 7, 2020·Journal of the Egyptian National Cancer Institute·Wafaa M RashedSameera Ezzat
Jun 18, 2020·Cancer Management and Research·Aiqing Ma, Rui Zhang
Nov 3, 2020·Frontiers in Genetics·Huancheng Wang, Jia Liu
Dec 11, 2020·Carcinogenesis·Xiongfeng PanAizhong Liu
Jan 13, 2021·Pharmaceuticals·Francesca Matilde SchipillitiFabio Gelsomino
Feb 11, 2021·Journal of Clinical Medicine·Kei MoriyaHitoshi Yoshiji
Nov 10, 2020·Frontiers in Oncology·Chunye ZhangAaron C Ericsson
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Apr 19, 2021·International Journal of Biological Macromolecules·Na LiZunnan Huang
Jun 4, 2021·Journal of Hepatocellular Carcinoma·Alessandro GranitoFrancesco Tovoli

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