Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease.

Translational Research : the Journal of Laboratory and Clinical Medicine
Andrew L DurhamIan M Adcock

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases of the airway, although the drivers and site of the inflammation differ between diseases. Asthmatics with a neutrophilic airway inflammation are associated with a poor response to corticosteroids, whereas asthmatics with eosinophilic inflammation respond better to corticosteroids. Biologicals targeting the Th2-eosinophil nexus such as anti-interleukin (IL)-4, anti-IL-5, and anti-IL-13 are ineffective in asthma as a whole but are more effective if patients are selected using cellular (eg, eosinophils) or molecular (eg, periostin) biomarkers. This highlights the key role of individual inflammatory mediators in driving the inflammatory response and for accurate disease phenotyping to allow greater understanding of disease and development of patient-oriented antiasthma therapies. In contrast to asthmatic patients, corticosteroids are relatively ineffective in COPD patients. Despite stratification of COPD patients, the results of targeted therapy have proved disappointing with the exception of recent studies using CXC chemokine receptor (CXCR)2 antagonists. Currently, several other novel mediator-targeted drugs are undergoing clinical trials. A...Continue Reading

Citations

Nov 2, 2018·The Journal of Clinical Investigation·Stephanie A ChristensonPrescott G Woodruff
Jun 27, 2019·Environmental Toxicology·Seong-Gyeol HongSung-Tae Yee
Sep 8, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Katrina Dean, Robert Niven
Mar 16, 2018·Mediators of Inflammation·Marta Stolarczyk, Bob J Scholte
Jun 23, 2020·The Journal of International Medical Research·Qing-Qing YiQing Chang
Feb 20, 2018·Experimental and Therapeutic Medicine·Lei YangLiang Dong
Jun 24, 2017·Journal of Oral Science·Hossam AsaadOmar Kujan
Jun 30, 2017·Primate Biology·Franziska Dahlmann, Katherina Sewald
Sep 24, 2016·Journal of Clinical Medicine·Ji Young YheeRichard Seonghun Nho
Oct 25, 2016·Expert Opinion on Therapeutic Patents·Jason G KettleRichard Woessner
May 13, 2017·Immunity, Inflammation and Disease·Caroline SandenJonas S Erjefält
Nov 7, 2017·International Reviews of Immunology·Vijay Kumar, Ali Ahmad
Jun 9, 2018·American Journal of Respiratory and Critical Care Medicine·Daniel LightwoodRoger T Palframan
Mar 22, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Michael J HughesElizabeth Sapey
Sep 30, 2016·Clinical Reviews in Allergy & Immunology·Fa-Ping WangHui Mao
Dec 16, 2017·Expert Review of Respiratory Medicine·Paola RoglianiGiuseppe De Angelis
Dec 25, 2019·Drug Delivery and Translational Research·Gauthami PulivendalaChandraiah Godugu
Sep 2, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen J Gurczynski, Bethany B Moore
Dec 10, 2020·The Cochrane Database of Systematic Reviews·Tim DonovanIain Crossingham
Jan 8, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Arian GhassemianHarold Kim
Feb 19, 2021·The Journal of Biological Chemistry·Nicola J DarlingPhilip Cohen
Feb 23, 2021·Asian Journal of Pharmaceutical Sciences·Panoraia I SiafakaEvren Atlıhan Gündoğdu
Sep 4, 2021·European Journal of Pharmacology·Siddhi JainPawan Sharma
Sep 11, 2021·Chemico-biological Interactions·Md Sadique HussainHari S Sharma
Oct 7, 2021·Critical Reviews in Food Science and Nutrition·Yinghan ChanKamal Dua
Sep 4, 2019·Respiration; International Review of Thoracic Diseases·Stephan F van Eeden, James C Hogg

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Methods Mentioned

BETA
biopsies
bronchoalveolar lavage

Clinical Trials Mentioned

ISRCTN75169762
NCT01000506
NCT01691521
NCT01691508
NCT02075255
NCT02322775
NCT01928771
NCT02258542
NCT00930163
NCT02281357

Software Mentioned

SARP

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