Targeted approaches for the management of metastatic prostate cancer.

Current Oncology Reports
Kathleen W Beekman, Maha Hussain

Abstract

Huggins and Hodges described the first systemic targeted therapy for prostate cancer in 1941 with their report on the effects of androgen ablation in men with metastatic disease. Since that time, researchers have identified multiple additional "targets" that may be important in prostate cancer tumorigenesis. These areas include continued emphasis on the androgen receptor in the androgen-independent state, parallel growth pathways such as AKT and HER2 that may act in conjunction or independently of the androgen receptor, the supporting environment that allows for the development of metastatic disease, and standard cytotoxic targets, such as the microtubule. This review is intended to highlight these potential targets and several of the agents that are under development in the treatment of prostate cancer.

References

Apr 22, 1994·Science·P C BrooksD A Cheresh
Aug 17, 1999·Journal of Medicinal Chemistry·M A DechantsreiterH Kessler
Mar 20, 2002·Nature Reviews. Cancer·B J Feldman, D Feldman
Mar 21, 2002·Nature Reviews. Cancer·P MarksW K Kelly
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A CarducciRobert J Padley
May 4, 2002·Neoplasia : an International Journal for Oncology Research·Monika SchmelzRaymond B Nagle
Jul 18, 2002·Nature Reviews. Drug Discovery·Ricky W Johnstone
Nov 30, 2002·Expert Opinion on Investigational Drugs·William K KellyPaul A Marks
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A CarducciJoel B Nelson
Aug 14, 2003·Journal of Molecular Endocrinology·B NanM Marcelli
Oct 23, 2003·Seminars in Oncology·David B SolitNeal Rosen
Nov 12, 2003·The Journal of Urology·Joel B Nelson
Dec 19, 2003·Expert Opinion on Investigational Drugs·Roberto R Rosato, Steven Grant
Dec 20, 2003·Current Drug Metabolism·Paramita M GhoshJeffrey I Kreisberg
Mar 3, 2004·Journal of Cellular Biochemistry·Kwanchanit TantivejkulKenneth J Pienta
Mar 27, 2004·Cancer Treatment and Research·Theresa A Guise, Khalid S Mohammad
Aug 26, 2004·Advances in Cancer Research·Paul A MarksWilliam Kevin Kelly
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 8, 2004·The New England Journal of Medicine·Daniel P PetrylakE David Crawford
Oct 12, 2004·Hematology/oncology Clinics of North America·Alexander A Parikh, Lee M Ellis
Nov 3, 2004·Cancer Research·Sucharita BandyopadhyayKounosuke Watabe
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew P GoetzCharles Erlichman
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew D GalskyW Kevin Kelly
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean L GremRichard H Wilson
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fairooz F KabbinavarSomnath Sarkar
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ramesh K RamanathanMerrill J Egorin
May 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William Kevin KellyVictoria M Richon
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Udai BanerjiIan Judson

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Citations

Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shan LuZhongyun Dong

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