Targeted combination prevention to support female sex workers in Zimbabwe accessing and adhering to antiretrovirals for treatment and prevention of HIV (SAPPH-IRe): a cluster-randomised trial

The Lancet. HIV
F M CowanJ R Hargreaves

Abstract

Strengthening engagement of female sex workers with health services is needed to eliminate HIV. We assessed the efficacy of a targeted combination intervention for female sex workers in Zimbabwe. We did a cluster-randomised trial from 2014 to 2016. Clusters were areas surrounding female sex worker clinics and were enrolled in matched pairs. Sites were randomly assigned (1:1) to receive usual care (free sexual-health services supported by peer educators, including HIV testing on demand, referral for antiretroviral therapy [ART], and health education) or an intervention that supported additional regular HIV testing, on-site initiation of ART, pre-exposure prophylaxis, adherence, and intensified community mobilisation. The primary outcome was the proportion of all female sex workers with HIV viral load 1000 copies per mL or greater, assessed through respondent-driven sampling surveys. We used an adapted cluster-summary approach to estimate risk differences. This trial is registered with Pan African Clinical Trials Registry, number PACTR201312000722390. We randomly assigned 14 clusters to usual care or the intervention (seven in each group). 3612 female sex workers attended clinics in the usual-care clusters and 4619 in the interve...Continue Reading

Citations

Jul 23, 2019·Journal of the International AIDS Society·Frances M CowanAndrew N Phillips
Jun 21, 2019·Current Opinion in HIV and AIDS·Frances M CowanDeanna L Kerrigan
Sep 25, 2019·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Jaclyn SheaKathryn E Lancaster
Sep 7, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Winter A OliloUNKNOWN SEARCH Collaboration
Oct 29, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marie A BraultSten H Vermund
Nov 26, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·James R HargreavesJames J Lewis
Nov 26, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Joshua A Salomon
Feb 16, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elizabeth FearonJames R Hargreaves
Jul 17, 2020·Culture, Health & Sexuality·Lisa LazarusRobert Lorway
Apr 10, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elizabeth FearonJames R Hargreaves
May 15, 2020·Nature Medicine·Elizabeth M Irungu, Jared M Baeten
Feb 18, 2020·Journal of the International AIDS Society·Anna L BowringMargaret Hellard
Apr 17, 2020·Current HIV/AIDS Reports·Marie A BraultSten H Vermund
Aug 11, 2020·Current HIV/AIDS Reports·Rebecca JoplingMelanie Amna Abas
Oct 13, 2020·AIDS Care·Joanna BuszaFrances M Cowan
Apr 7, 2019·The Lancet. HIV·Sunil S SolomonUNKNOWN Indian National Collaboration on AIDS Study
Apr 3, 2021·Journal of Viral Hepatitis·Blessing DzingiraiNyashadzaishe Mafirakureva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved