Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice

Cardiovascular Research
Hidenori MatsusakaHiroyuki Tsutsui

Abstract

Apoptosis may play an important role in cardiac remodeling after myocardial infarction (MI). p53 is a well-known proapoptotic factor. However, its pathophysiological significance in these conditions remains unclear. We thus examined the effects of target deletion of the p53 gene on post-MI hearts. Anterior MI was created in male heterozygous p53-deficient (p53(+/-); n = 28) mice and sibling wild-type (p53(+/+); n = 29) mice by ligating the left coronary artery. By day 7, p53(+/-) mice had significantly better survival rate than p53(+/+) mice (89% vs. 69%, P < 0.05). Notably, p53(+/-) mice had a significantly lower incidence of left ventricular (LV) rupture (7% vs. 28%, P < 0.05) despite comparable infarct size (60 +/- 2% vs. 59 +/- 2%, P = NS), heart rate (488 +/- 15 vs. 489 +/- 17 bpm, P = NS), or mean arterial blood pressure (80 +/- 2 vs. 78 +/- 3 mm Hg, P = NS). The extent of infiltrating interstitial cells including macrophages into the post-MI hearts was not altered by the deletion of p53. Further, collagen deposition as well as the zymographic MMP-2 and -9 activities were comparable between p53(+/-) and p53(+/+) mice with MI. However, the p53(+/-) mice had a significantly thicker infarct wall. The number of TUNEL-positive...Continue Reading

Citations

Dec 22, 2011·Nature Communications·Praphulla C ShuklaSubodh Verma
Jan 23, 2008·The Journal of Experimental Medicine·Masashi ShimazakiAkira Kudo
May 17, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Christopher J CarrollPaul A Townsend
Mar 12, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Prasanna KrishnamurthyRaj Kishore
Aug 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chang-Hoon WooJun-ichi Abe
Jul 3, 2010·Cold Spring Harbor Perspectives in Biology·Andrei V Gudkov, Elena A Komarova
Jul 26, 2012·Science Signaling·Chang-Lung LeeDavid G Kirsch
Jan 21, 2012·Pharmacology & Therapeutics·Xiao-Ming GaoXiao-Jun Du
Dec 2, 2014·Autonomic Neuroscience : Basic & Clinical·Wesley G CorrêaHelio C Salgado
Dec 30, 2014·Cell Communication and Signaling : CCS·Carla J AguiarM Fatima Leite
Oct 14, 2009·Trends in Molecular Medicine·Joana D AmaralCecília M P Rodrigues
May 27, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Paul S Pagel
Sep 24, 2015·Journal of Molecular and Cellular Cardiology·Shinji HayanoToyoaki Murohara
Mar 25, 2015·Trends in Cardiovascular Medicine·Sahana Suresh BabuPrasanna Krishnamurthy
Nov 10, 2011·The American Journal of Pathology·Ulrich HofmannGeorg Ertl
Aug 31, 2007·Life Sciences·Klara BrixiusWilhelm Bloch
Jun 19, 2009·Toxicologic Pathology·Eliahu GolombHerzl Schwalb
Oct 23, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Shigemiki OmiyaKinya Otsu
Sep 7, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Soichi SanoKenneth Walsh
Apr 24, 2010·Circulation Research·Atsuhiko T NaitoIssei Komuro
Apr 14, 2018·Circulation Research·Kathleen M BroughtonMark A Sussman
Mar 24, 2007·Nature Reviews. Molecular Cell Biology·Karen H Vousden, David P Lane
Feb 19, 2008·Coronary Artery Disease·Burton E SobelDouglas J Taatjes
Oct 16, 2009·Cardiology in Review·David C SaneRichard C Becker
Apr 19, 2019·Canadian Journal of Physiology and Pharmacology·Hongmei PengNour-Eddine Rhaleb
Jul 30, 2014·International Journal of Molecular Medicine·Miho SuzukiYasuko Kitagishi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.