Targeted delivery of growth factors in ischemic stroke animal models

Expert Opinion on Drug Delivery
Taiyoun Rhim, Minhyung Lee

Abstract

Ischemic stroke is caused by reduced blood supply and leads to loss of brain function. The reduced oxygen and nutrient supply stimulates various physiological responses, including induction of growth factors. Growth factors prevent neuronal cell death, promote neovascularization, and induce cell growth. However, the concentration of growth factors is not sufficient to recover brain function after the ischemic damage, suggesting that delivery of growth factors into the ischemic brain may be a useful treatment for ischemic stroke. In this review, various approaches for the delivery of growth factors to ischemic brain tissue are discussed, including local and targeting delivery systems. To develop growth factor therapy for ischemic stroke, important considerations should be taken into account. First, growth factors may have possible side effects. Thus, concentration of growth factors should be restricted to the ischemic tissues by local administration or targeted delivery. Second, the duration of growth factor therapy should be optimized. Growth factor proteins may be degraded too fast to have a high enough therapeutic effect. Therefore, delivery systems for controlled release or gene delivery may be useful. Third, the delivery sy...Continue Reading

References

Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BeckA Wree
May 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W R SchäbitzW Hacke
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O PetersU Dirnagl
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·D Wu, W M Pardridge
Apr 20, 1999·Cerebrovascular Diseases·H AyS P Finklestein
Jun 5, 1999·Molecular and Cellular Neurosciences·M S AiraksinenM Saarma
Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·W T GodbeyA G Mikos
Oct 6, 2000·The Journal of Clinical Investigation·Z G ZhangM Chopp
Oct 29, 2000·Journal of Applied Physiology·J C ChávezJ C LaManna
Aug 21, 2001·Clinical Pharmacokinetics·J M HarrisM Modi
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·N ShiW M Pardridge
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Bi-Wei SongWilliam M Pardridge
Apr 24, 2002·Seminars in Cell & Developmental Biology·Peter Carmeliet, Erik Storkebaum
Oct 23, 2002·Brain : a Journal of Neurology·Heike J SchochHugo H Marti
Oct 29, 2002·Annals of Neurology·Ertugrul KilicMathias Bähr
Feb 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthias EndresRudolf Jaenisch
Apr 5, 2003·Stroke; a Journal of Cerebral Circulation·Ulkan KilicMathias Bähr
Jul 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maria BellomoGioacchino Calapai
Apr 28, 2004·Advanced Drug Delivery Reviews·Evan C UngerReena Zutshi
Jun 12, 2004·Stroke; a Journal of Cerebral Circulation·Shigeru TanakaMasatsugu Hori
Jun 2, 2005·Nature Reviews. Neuroscience·Michael Brines, Anthony Cerami
Feb 14, 2006·Critical Reviews in Eukaryotic Gene Expression·Han Chang KangYou Han Bae
Apr 22, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Yongzhong WangJens Kastrup
Jul 18, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jung-Bin KimJa-Kyeong Lee
Jul 29, 2006·Stroke; a Journal of Cerebral Circulation·Tohru KobayashiOlle Lindvall

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Citations

Jan 8, 2019·Expert Opinion on Biological Therapy·Stavros SpiliopoulosElias Brountzos
Jan 10, 2020·Current Drug Targets·Samira AsgharzadeFatemeh Forouzanfar
Sep 24, 2020·International Journal of Molecular Sciences·Vage MarkosyanRustem Islamov
Mar 3, 2018·Frontiers in Pharmacology·Mikhail E SokolovRustem R Islamov
Mar 11, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Hassan BardaniaFarid Dorkoosh
May 26, 2021·Stem Cell Reviews and Reports·Mohammad Saied SalehiAfshin Borhani-Haghighi
Aug 14, 2021·Acta Pharmaceutica Sinica. B·Chao LiChen Jiang

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