Targeted delivery of liquid microvolumes into the lung

Proceedings of the National Academy of Sciences of the United States of America
Jinho KimGordana Vunjak-Novakovic

Abstract

The ability to deliver drugs to specific sites in the lung could radically improve therapeutic outcomes of a variety of lung diseases, including cystic fibrosis, severe bronchopneumonia, chronic obstructive pulmonary disease, and lung cancer. Using conventional methods for pulmonary drug administration, precise, localized delivery of exact doses of drugs to target regions remains challenging. Here we describe a more controlled delivery of soluble reagents (e.g., drugs, enzymes, and radionuclides) in microvolume liquid plugs to targeted branches of the pulmonary airway tree: upper airways, small airways (bronchioles), or the most distal alveoli. In this approach, a soluble liquid plug of very small volume (<1 mL) is instilled into the upper airways, and with programmed air ventilation of the lungs, the plug is pushed into a specific desired (more distal) airway to achieve deposition of liquid film onto the lung epithelium. The plug volume and ventilation conditions were determined by mathematical modeling of plug transport in a tubular geometry, and targeted liquid film deposition was demonstrated in rat lungs by three different in vivo imaging modalities. The experimental and modeling data suggest that instillation of microvolu...Continue Reading

References

Nov 1, 1979·The Anatomical Record·H C YehM T Duggan
Jul 1, 1990·The Journal of Clinical Investigation·S Hawgood, J A Clements
Feb 1, 1989·Respiration Physiology·R D Kamm, R C Schroter
Sep 1, 1987·The American Review of Respiratory Disease·W H TooleyM A Schlueter
Dec 1, 1973·Respiration Physiology·R Reifenrath, I Zimmermann
Jan 1, 1984·Clinical Pharmacokinetics·S M Pond, T N Tozer
Jun 1, 1994·Journal of Applied Physiology·S H HsuA M Jamieson
Mar 1, 1994·Archives of Disease in Childhood·A J Henderson
Nov 1, 1993·Journal of Applied Physiology·F F EspinosaR D Kamm
Jun 20, 1997·Science·D A EdwardsR Langer
Jul 9, 1998·Journal of Applied Physiology·D HalpernJ B Grotberg
Jan 14, 1999·Journal of Applied Physiology·F F Espinosa, R D Kamm
Apr 3, 2001·Nature Biotechnology·R Weissleder
May 23, 2001·Advanced Drug Delivery Reviews·K KhanvilkarD R Flanagan
Feb 6, 2002·The Journal of Gene Medicine·Patrice CholletJean-Luc Coll
Feb 8, 2002·Cell·Ricky W JohnstoneScott W Lowe
Nov 18, 2003·British Journal of Clinical Pharmacology·N R Labiris, M B Dolovich
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·S P ConwayD G Peckham
Jun 28, 2005·Investigative Ophthalmology & Visual Science·Hiroshi IkagawaMasahiro Zako
Aug 23, 2005·Proceedings of the American Thoracic Society·John S PattonJeffry G Weers
Jan 20, 2007·Journal of Colloid and Interface Science·Cédric P OdyEmmanuel de Langre
Jan 24, 2008·Nature Clinical Practice. Cardiovascular Medicine·Adnan Kastrati, Albert Schömig
Jan 27, 2009·Advanced Drug Delivery Reviews·Samuel K LaiJustin Hanes
Aug 26, 2009·Physics of Fluids·Y ZhengJ B Grotberg
Feb 9, 2012·Advanced Drug Delivery Reviews·Joy Conway
Apr 17, 2014·Advanced Drug Delivery Reviews·M HoppentochtA H de Boer
Dec 5, 2014·Respiration; International Review of Thoracic Diseases·Katharine Hurt, Diana Bilton

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Citations

Aug 11, 2016·Annals of the American Thoracic Society·Darcy E WagnerUNKNOWN ATS Subcommittee on Stem Cells and Cell Therapies
Sep 23, 2016·Frontiers in Pharmacology·Miquéias Lopes-Pacheco
Jul 19, 2018·Expert Opinion on Drug Delivery·Nashwa OsmanImran Saleem
Jul 12, 2018·Human Gene Therapy Methods·Chantelle McIntyreDavid Parsons
May 9, 2019·Nature Communications·Brandon A GuenthartMatthew Bacchetta
Oct 14, 2017·Scientific Reports·Jinho KimGordana Vunjak-Novakovic
Dec 25, 2019·Drug Delivery and Translational Research·Gauthami PulivendalaChandraiah Godugu
May 1, 2020·Frontiers in Bioengineering and Biotechnology·N Valerio Dorrello, Gordana Vunjak-Novakovic
Jun 5, 2021·Cell Stem Cell·Daniel Naveed TavakolGordana Vunjak-Novakovic
Jul 1, 2021·Acta Biomaterialia·Jiawen ChenJinho Kim

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