Targeted delivery of nanomedicines.

ISRN Pharmacology
Vinod Kumar Khanna

Abstract

The role of targeting of the diseased region by a drug is emphasized. The rationale for resorting to nanomaterials as drug carriers is explained. A clear understanding of the biological environment, its degradation in diseased condition, and the interaction of the drug with it in normal condition and during illness lie at the core of successful drug delivery. Passive and active drug targeting approaches are differentiated. Commonly used drug targets, targeting ligands, and nanoscale systems are elaborated. Mechanisms of internalization of nanomedicines and circumventing P-glycoprotein mediated resistance are outlined. The paper presents an overview of the current scenario of targeted transportation of nanomedicines to the affected organ and suggests future research directions.

References

Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K S SoppimathW E Rudzinski
Oct 3, 2002·Nature Reviews. Cancer·Theresa M Allen
Jun 19, 2004·Drug Delivery·Giulio F PaciottiLawrence Tamarkin
Jul 20, 2004·Nature Biotechnology·Xiaohu GaoShuming Nie
Feb 3, 2005·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Feb 19, 2005·Seminars in Oncology·John W ParkFrancis J Martin
Feb 22, 2005·Advanced Drug Delivery Reviews·Bhawna GuptaVladimir P Torchilin
Feb 25, 2005·Current Pharmaceutical Biotechnology·O KayserN Hernández-Trejo
Jan 28, 2006·Journal of Cellular Biochemistry·T C Yih, M Al-Fandi
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
Jul 4, 2006·Pharmacology & Therapeutics·Nobuhiro Nishiyama, Kazunori Kataoka
Aug 11, 2006·Nature Reviews. Cancer·Ruth Duncan
Sep 6, 2006·Journal of Liposome Research·Raymond M SchiffelersGert Storm
Apr 12, 2007·Critical Reviews in Therapeutic Drug Carrier Systems·Shuhua BaiFakhrul Ahsan
Aug 4, 2007·Lasers in Medical Science·Xiaohua HuangMostafa A El-Sayed
Oct 27, 2007·Lasers in Surgery and Medicine·Xiaohua HuangMostafa A El-Sayed
Dec 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Paul PodsiadloNicholas A Kotov
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwangjae ChoDong M Shin
Mar 19, 2008·Molecular Cancer Therapeutics·Albert LoHan-Chung Wu
Jul 11, 2008·Expert Opinion on Biological Therapy·Andrew Z WangOmid C Farokhzad
Jul 22, 2008·Cases Journal·Ioannis EfthimiouIoannis Christoulakis
Jul 24, 2008·British Journal of Cancer·T LammersG Storm
Oct 3, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José L Arias
Jan 1, 2007·Recent Patents on Drug Delivery & Formulation·Natalie P Praetorius, Tarun K Mandal
Jan 7, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuxian SongYuhong Xu
Mar 21, 2009·Bioorganic & Medicinal Chemistry·Amir H Faraji, Peter Wipf
Dec 18, 2009·Current Medicinal Chemistry·L ZhangC-M Huang
Jan 1, 2010·Sensors·Young-Eun ChoiJoon Won Park
Jan 1, 2008·Nanotechnology, Science and Applications·Po C ChenAdegboyega K Oyelere

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Citations

Oct 6, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Pramod JagtapShalini Gupta
Feb 22, 2018·Journal of Drug Delivery·Sheikh Tasnim JahanAzita Haddadi
Nov 26, 2015·Journal of Complementary & Integrative Medicine·Ramalingam SripradhaNachimuthu Maithilikarpagaselvi
Oct 17, 2019·Nanomaterials·Jacinta Oliveira PinhoMaria Manuela Gaspar
Aug 24, 2019·Journal of Cellular Physiology·Ali Aghebati-MalekiLeili Aghebati-Maleki
Jul 14, 2019·Seminars in Cancer Biology·Balney RajithaGanji Purnachandra Nagaraju
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Disha N MoholkarKiran D Pawar
May 26, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Philip GrossenJörg Huwyler
Apr 13, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sónia RochaMarisa Freitas
Dec 23, 2020·Recent Patents on Anti-cancer Drug Discovery·Sankha Bhattacharya

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Methods Mentioned

BETA
surface plasmon resonance

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