Targeted delivery of short interfering RNAs--strategies for in vivo delivery

Recent Patents on Anti-cancer Drug Discovery
Ulrich WullnerStefan Barth

Abstract

RNA interference (RNAi) is a powerful endogenous process initiated by short double stranded RNAs, which results in sequence-specific posttranscriptional gene silencing. The ability to block the expression of any disease-causing or disease-related protein emphasizes the huge therapeutic potential of this technology. In a clinical setting, however, the use of RNAi-based therapeutics is limited by their short serum half lives and poor uptake into cells. In this review, we provide an overview of recent patents in the field of short interfering RNA (siRNA) delivery and discuss recent progress in the development of efficient siRNA delivery vehicles enhancing the pharmacokinetic properties of RNAi-based therapeutics and promoting cellular uptake.

Citations

Nov 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jason DolesMichael T Hemann
Aug 22, 2012·European Journal of Medicinal Chemistry·Qinchang ZhuMasaaki Kai
Jun 23, 2009·Bioorganic & Medicinal Chemistry·Yusuke SugaoTakuro Niidome
Sep 22, 2011·Wiley Interdisciplinary Reviews. RNA·Lance P Ford, Masoud M Toloue
Sep 5, 2013·Journal of the American Chemical Society·Yen-Lin Lin, Benoît Roux
Sep 11, 2018·Expert Opinion on Drug Delivery·Ikramy A KhalilHideyoshi Harashima
Sep 17, 2009·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Marta López-FragaAna Jiménez

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