PMID: 9182763May 30, 1997Paper

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

Cell
T KomoriT Kishimoto

Abstract

A transcription factor, Cbfa1, which belongs to the runt-domain gene family, is expressed restrictively in fetal development. To elucidate the function of Cbfa1, we generated mice with a mutated Cbfa1 locus. Mice with a homozygous mutation in Cbfa1 died just after birth without breathing. Examination of their skeletal systems showed a complete lack of ossification. Although immature osteoblasts, which expressed alkaline phophatase weakly but not Osteopontin and Osteocalcin, and a few immature osteoclasts appeared at the perichondrial region, neither vascular nor mesenchymal cell invasion was observed in the cartilage. Therefore, our data suggest that both intramembranous and endochondral ossification were completely blocked, owing to the maturational arrest of osteoblasts in the mutant mice, and demonstrate that Cbfa1 plays an essential role in osteogenesis.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H M ProsserM J Owen
Aug 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T IkedaS Yoshiki
Jul 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K IbarakiM F Young
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F P ReinholtD Heinegård
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H MiyoshiM Ohki
Aug 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M WeinrebG A Rodan
Nov 1, 1988·Endocrinology·N TakahashiT Suda
Jun 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M J SomermanW T Butler
Apr 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M NodaG A Rodan
May 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A SimeoneF Calabi
Oct 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K HirakawaS Nomura
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E OgawaY Ito
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·Q WangN A Speck
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·C BanerjeeG S Stein
Aug 1, 1996·Nature·P DucyG Karsenty
Jun 8, 1996·Annals of the New York Academy of Sciences·S MundlosB R Olsen
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·K SasakiT Komori

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Citations

Apr 23, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M InadaT Komori
Jun 9, 1998·Journal of Cellular Physiology·S PandipatiR T Franceschi
Jul 17, 1998·Developmental Genetics·G Karsenty
Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B K Hall, T Miyake
Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Barton, G Nucifora
Feb 15, 2001·The Journal of Experimental Zoology·B K Hall
Nov 21, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P Ducy
Sep 1, 2000·Journal of Cellular Biochemistry·N SelvamuruganN C Partridge
Jul 27, 2000·Journal of Cellular Physiology·H DrissiG S Stein
May 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Wen-Fang WangBjorn R Olsen
Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A HornerG H Nuckolls
Apr 25, 2001·Genes, Chromosomes & Cancer·N SpiekerR Versteeg
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Chouhei SakakuraYoshiaki Ito
Jan 12, 2002·Journal of Cellular Biochemistry·Andrea PlantJonathan H Tobias
Apr 23, 2002·Journal of Cellular Biochemistry·Kannan ThirunavukkarasuJude E Onyia
Sep 5, 2002·Journal of Cellular Biochemistry·Toshihisa Komori
Oct 25, 2002·Journal of Cellular Biochemistry·Marie A WheelerLaura J Mauro
Jun 16, 2001·Journal of Cellular Biochemistry·F GoriM B Demay
Aug 14, 2001·Journal of Cellular Biochemistry·Z S XiaoL D Quarles
Sep 25, 2004·Journal of Cellular Physiology·R MaromDafna Benayahu
Sep 25, 2004·Journal of Cellular Physiology·Irena ShurDafna Benayahu
Jun 30, 2000·Biochemical and Biophysical Research Communications·H KobayashiT Komori
Jul 25, 2000·Biochemical and Biophysical Research Communications·K Tsuji, M Noda
Jul 11, 2001·Biochemical and Biophysical Research Communications·M GydaB R Troen
Mar 28, 2007·Pathology Oncology Research : POR·Hye-Rim Park, Yong-Koo Park
Dec 5, 2009·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Stefan LossdörferAndreas Jäger
Jun 19, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Xudong LiGary Balian
Oct 13, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S-D JiangL-Y Dai
Sep 2, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S K BaniwalB Frenkel
Jan 14, 2009·Calcified Tissue International·C DierkesL Fink
May 9, 2009·Calcified Tissue International·Hee-Jung LeeJong-Young Lee
Dec 7, 2011·Calcified Tissue International·Bojian LiangGuang Zhou

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