Jun 27, 2006

Targeted disruption of the mouse Asna1 gene results in embryonic lethality

FEBS Letters
Rita MukhopadhyayH Bhattacharjee

Abstract

The bacterial ArsA ATPase is the catalytic component of an oxyanion pump that is responsible for resistance to arsenicals and antimonials. Homologues of the bacterial ArsA ATPase are widespread in nature. We had earlier identified the mouse homologue (Asna1) that exhibits 27% identity to the bacterial ArsA ATPase. To identify the physiological role of the protein, heterozygous Asna1 knockout mice (Asna1+/-) were generated by homologous recombination. The Asna1+/- mice displayed similar phenotype as the wild-type mice. However, early embryonic lethality was observed in homozygous Asna1 knockout embryos, between E3.5 (E=embryonic day) and E8.5 stage. These findings indicate that Asna1 plays a crucial role during early embryonic development.

  • References18
  • Citations27

References

  • References18
  • Citations27

Citations

Mentioned in this Paper

Fertility
Embryo
Metabolic Process, Cellular
Northern Blotting
ASNA1 gene
Golgi Apparatus
Exons
Genome
KDELR1 gene
C57BL/6 Mouse

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