Targeted doxorubicin delivery and release within breast cancer environment using PEGylated chitosan nanoparticles labeled with monoclonal antibodies.

International Journal of Biological Macromolecules
Omar HelmiWael Mamdouh

Abstract

Breast cancer has been one of the top chronic and life-threatening diseases worldwide. Nano-drug therapeutic systems have proved their efficacy as a selective treatment compared to the traditional ones that are associated with serious adverse effects. Here, biodegradable chitosan nanoparticles (CSNPs) were synthesized to provide selective and sustained release of doxorubicin (DOX) within the breast tumor microenvironment. CSNPs surface was modified using Polyethylene glycol (PEG) to enhance their blood circulation timing. To provide high drug selectivity, CSNPs functionalized with two different types of breast cancer-specific monoclonal antibodies (mAb); anti-human mammaglobin (Anti-hMAM) and anti-human epidermal growth factor (Anti-HER2). Anti-hMAM PEGylated DOX loaded CSNPs and Anti-HER2 PEGylated DOX loaded CSNPs nano-formulations were the most cytotoxic against MCF-7 cancer cells than L-929 normal cells compared to free DOX. Finally, we believe that dose-dependent system toxicity of freely ingested DOX can be managed with such targeted nano-formulated drug delivery platforms.

References

Mar 9, 2002·Plastic and Reconstructive Surgery·Hideo NakajimaSadakazu Aiso
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoen Ju SonSeo Young Jeong
Dec 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B LinderholmR Henriksson
Nov 3, 2004·Carbohydrate Research·Lifeng QiXiangfei Zou
Jun 1, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M De LaurentiisS De Placido
Sep 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xinge ZhangChaoxing Li
Jul 16, 2008·Journal of Materials Science. Materials in Medicine·X G ZhangC X Li
Mar 25, 2009·Cancer Cell International·Lian ZuoShaojin You
Sep 8, 2010·AAPS PharmSciTech·Manee Luangtana-AnanKeiji Yamamoto
Oct 19, 2010·International Journal of Food Microbiology·Ming KongHyun Jin Park
Sep 29, 2011·International Journal of Molecular Sciences·Mansor Bin AhmadJenn Jye Lim
Oct 7, 2011·International Journal of Nanomedicine·Parisa YousefpourRassoul Dinarvand
Nov 15, 2011·International Journal of Pharmaceutics·Rishi PaliwalSuresh P Vyas
Jan 11, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zohreh Amoozgar, Yoon Yeo
Jun 6, 2012·Advanced Drug Delivery Reviews·Tennyson Doane, Clemens Burda
Feb 21, 2013·International Journal of Pharmaceutics·Zeting YuanWei Wang
May 30, 2013·Journal of Biomaterials Science. Polymer Edition·Yiyi WangYourong Duan
Dec 4, 2013·Cold Spring Harbor Perspectives in Biology·Ira Mellman, Yosef Yarden
Jan 24, 2014·International Journal of Pharmaceutics·Ubonvan TermsarasabDae-Duk Kim
Jan 1, 2013·Hereditary Genetics : Current Research·Kartik AysolaVeena N Rao
Sep 1, 2013·Journal of Nanopharmaceutics and Drug Delivery·Mahdi KarimiHossein Naderi-Manesh
May 15, 2016·Carbohydrate Polymers·Paula I P SoaresJoão Paulo Borges
May 27, 2016·Analytical and Bioanalytical Chemistry·Gabriele Dadalt SoutoHugh James Byrne
Sep 7, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xubo ZhaoPeng Liu
Sep 25, 2016·Journal of Pharmaceutical Sciences·Emelie AhnfeltHans Lennernäs
Mar 20, 2018·Scientific Reports·Sruthi SreekumarGustavo R Rivera-Rodriguez
Jun 5, 2018·Trends in Cancer·Carolina Vicente-DueñasIsidro Sánchez-García
Oct 14, 2018·Colloids and Surfaces. B, Biointerfaces·Abhishesh Kumar MehataMadaswamy S Muthu
Jan 15, 2019·Current Pharmaceutical Design·Evangelos OikonomouDimitris Tousoulis
Mar 25, 2019·Pharmaceutics·Constantin MircioiuIon Mircioiu
Feb 26, 2018·Polymers·Javier Pérez QuiñonesCarlos Peniche
Jun 14, 2019·International Journal of Biological Macromolecules·Amirhosein Kefayat, Sedigheh Vaezifar
Sep 19, 2019·Cancer Cell·Julian M HessGad Getz
Aug 30, 2020·Signal Transduction and Targeted Therapy·Akhand Pratap SinghPralay Maiti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.