Targeted drug delivery in gynaecology: the first uterine pass effect

Human Reproduction
Carlo BullettiF Franceschetti

Abstract

The objective was to verify the hypothesis of a 'first uterine pass effect' or direct preferential vagina-to-uterus transport, suggested by the evidence of higher than expected uterine tissue concentrations after vaginal administration of progesterone; we used a human ex-vivo uterine perfusion model. A mixture of tritiated (3H) and unlabelled progesterone was applied to the cuff of vaginal tissue remaining attached to the cervix after hysterectomy. At the end of the perfusion period (up to 12 h), 3H and 14C radioactivity was measured in samples of uterine tissue. Tritiated water and [14C]dextran were tested to determine the extent of non-specific vagina-to-uterus transport (leaks). Finally, sections of uterine tissue exposed only to [3H]progesterone were prepared for autoradiography. By 4-5 h after application progesterone had diffused to the entire uterus and had reached a steady state; 4 h after application, progesterone concentrations reached 185 +/- 155 and 254 +/- 305 ng/100 mg of endometrial and myometrial tissue respectively. Endometrial extraction of progesterone was higher when the experiment was performed on uteri obtained during the luteal phase (280 +/- 156 ng/100 mg of endometrial tissue) than those removed during ...Continue Reading

Citations

Feb 9, 2012·Journal of Assisted Reproduction and Genetics·Brian M Berger, James A Phillips
Oct 16, 1999·Fertility and Sterility·L A Fitzpatrick, A Good
Dec 11, 1999·Fertility and Sterility·K JobanputraW E Gibbons
Aug 15, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·B ChanrachakulP Punyavachira
Sep 27, 2000·Obstetrics and Gynecology·B ChanrachakulP Punyavachira
Dec 8, 2000·Steroids·D de Ziegler, R Fanchin
Oct 24, 1998·Journal of Reproductive Immunology·D de ZieglerC Bulletti
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M LudwigK Diedrich
Oct 15, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ernest H Y NgPak-Chung Ho
May 1, 2001·Acta Obstetricia Et Gynecologica Scandinavica·M Ludwig, K Diedrich
Sep 21, 2000·Cephalalgia : an International Journal of Headache·S D Silberstein, B de Lignières
Dec 31, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Catharine D BatesJane E Norman
Jan 15, 2002·Journal of Women's Health & Gender-based Medicine·S ShanthaM P Warren
Jul 9, 2013·Journal of Mid-life Health·Sonia Malik
Jan 23, 2014·Pharmaceutical Research·José das NevesBruno Sarmento
Jan 2, 2014·The Journal of Antimicrobial Chemotherapy·R Karl MalcolmJohn P Moore
Mar 13, 2014·Journal of Assisted Reproduction and Genetics·Paula C BradyCatherine Racowsky
May 28, 2014·The Journal of Antimicrobial Chemotherapy·Diarmaid J MurphyR Karl Malcolm
Sep 24, 2004·Journal of Women's Health·Mary Justin-TemuGuy Van Den Mooter
Oct 13, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gian Carlo Di RenzoSandro Gerli
Mar 3, 2001·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F M ReisF Petraglia
Jan 23, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fadi Ghazi MirzaClaire Pexman-Fieth
Sep 7, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C FiciciogluH Canova
Feb 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei-Ze LiChun-Jing Dong
Jun 21, 2013·Drug Development and Industrial Pharmacy·Srinivasan ShanmugamJong Soo Woo
Feb 9, 2016·Reproductive Toxicology·Anthony R ScialliKary E Thompson
Aug 23, 2005·Climacteric : the Journal of the International Menopause Society·H Kuhl
Jan 29, 2016·Fertility and Sterility·Robert F Casper, Elena H Yanushpolsky
Aug 11, 2007·The Journal of Obstetrics and Gynaecology Research·Mohamed Furukan Mohamed Rameez, Indra Malik Rodrigo Goonewardene
Jun 19, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wei-Ze LiZhang Chun-Feng
Mar 1, 2012·Obstetrics and Gynecology Clinics of North America·Carla E Ransom, Amy P Murtha
Nov 8, 2015·Reproductive Toxicology·Anthony R ScialliKary E Thompson
May 9, 2003·Reproductive Biomedicine Online·Alan S Penzias, Michael M Alper
May 12, 2009·Advanced Drug Delivery Reviews·Margit M Janát-AmsburyC Matthew Peterson
Feb 27, 2009·Fertility and Sterility·Eman A ElgindyMostafa Shafiek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.