Targeted drug delivery to the peripheral nervous system using gene therapy.

Neuroscience Letters
Darren WolfeDavid J Fink

Abstract

Gene transfer to target delivery of neurotrophic factors to the primary sensory afferent for treatment of polyneuropathy, or of inhibitory neurotransmitters for relief of chronic pain, offers the possibility of a highly selective targeted release of bioactive molecules within the nervous system. Preclinical studies with non-replicating herpes simplex virus (HSV)-based vectors injected into the skin to transduce neurons in the dorsal root ganglion have demonstrated efficacy in reducing-pain related behaviors in animal models of inflammatory pain, neuropathic pain, and pain caused by cancer, and in preventing progression of sensory neuropathy caused by toxins, chemotherapeutic drugs or resulting from diabetes. Successful completion of the first phase 1 clinical trial of HSV-mediated gene transfer in patients with intractable pain from cancer has set the stage for further clinical trials of this approach.

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Citations

Jun 19, 2013·Current Diabetes Reports·Roy Freeman
Nov 16, 2013·The Journal of Clinical Investigation·Huijing WangAnnemieke Kavelaars
Apr 29, 2014·Molecular and Cellular Neurosciences·Josef PletichaAndreas S Beutler
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ahmet Höke
May 13, 2015·Molecular Pain·Jean-Marc G GuedonShuanglin Hao
Jan 29, 2016·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Tamina Johnson, Piyush Koria
Dec 22, 2016·Expert Opinion on Investigational Drugs·Viola Spahn, Christoph Stein
Nov 20, 2018·Expert Opinion on Therapeutic Targets·Shaogen WuYuan-Xiang Tao
Feb 15, 2018·PLoS Biology·Hanneke L D M WillemenNiels Eijkelkamp
Dec 6, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Qiang WuYuan-Xiang Tao
Dec 14, 2018·Frontiers in Neuroscience·Kelly A Langert, Eric M Brey
Jan 30, 2021·Scientific Reports·Neeraj KatiyarSahadev A Shankarappa
Oct 15, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yong YangYuan-Xiang Tao
Jun 8, 2021·Virology : Research and Treatment·Prapti H ModyJuliet V Spencer

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