Targeted Drug Delivery via the Use of ECM-Mimetic Materials

Frontiers in Bioengineering and Biotechnology
Jeongmin HwangKristi L Kiick

Abstract

The use of drug delivery vehicles to improve the efficacy of drugs and to target their action at effective concentrations over desired periods of time has been an active topic of research and clinical investigation for decades. Both synthetic and natural drug delivery materials have facilitated locally controlled as well as targeted drug delivery. Extracellular matrix (ECM) molecules have generated widespread interest as drug delivery materials owing to the various biological functions of ECM. Hydrogels created using ECM molecules can provide not only biochemical and structural support to cells, but also spatial and temporal control over the release of therapeutic agents, including small molecules, biomacromolecules, and cells. In addition, the modification of drug delivery carriers with ECM fragments used as cell-binding ligands has facilitated cell-targeted delivery and improved the therapeutic efficiency of drugs through interaction with highly expressed cellular receptors for ECM. The combination of ECM-derived hydrogels and ECM-derived ligand approaches shows synergistic effects, leading to a great promise for the delivery of intracellular drugs, which require specific endocytic pathways for maximal effectiveness. In this ...Continue Reading

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Citations

Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Luis Abelardo Villarruel MendozaPaolo Nicolas Catalano
Feb 13, 2021·Journal of Personalized Medicine·Nithya Subrahmanyam, Hamidreza Ghandehari
Nov 25, 2020·Pharmaceutics·Alessandra GirottiFrancisco Javier Arias
Jun 12, 2021·Bioconjugate Chemistry·Dvir PoplingerLeonid Patsenker
Jun 28, 2021·Drug Delivery and Translational Research·Samira Aghlara-FotovatOmid Veiseh
Jun 24, 2021·BioMed Research International·Ryan A Behmer HansenSamuel E Senyo

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Methods Mentioned

BETA
xenograft
transfection
transfections
Flow-activated cell sorting

Software Mentioned

ONPATTRO

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