Targeted fascicular biopsy of the sciatic nerve and its major branches: rationale and operative technique

Neurosurgical Focus
Stepan CapekRobert J Spinner

Abstract

OBJECT Nerve biopsy is typically performed in distal, noncritical sensory nerves without using imaging to target the more involved regions. The yield of these procedures rarely achieves more than 50%. In selected cases where preoperative evaluation points toward a more localized (usually a more proximal) process, targeted biopsy would likely capture the disease. Synthesis of data obtained from clinical examination, electrophysiological testing, and MRI allows biopsy of a portion of the major mixed nerves safely and efficiently. Herein, experiences with the sciatic nerve are reported and a description of the operative technique is provided. METHODS All cases of sciatic nerve biopsy performed between 2000 and 2014 were reviewed. Only cases of fascicular nerve biopsy approached from the buttock or the posterior aspect of the thigh were included. Demographic data, clinical presentation, and the presence of percussion tenderness for each patient were recorded. Reviewed studies included electrodiagnostic tests and imaging. Previous nerve and muscle biopsies were noted. All details of the procedure, final pathology, and its treatment implications were recorded. The complication rate was carefully assessed for temporary as well as perm...Continue Reading

References

Mar 1, 1990·Yonsei Medical Journal·S J Oh
Jul 1, 1997·Journal of Neurosurgery·M K AbouzahrM Corbo
Jul 29, 1999·Skeletal Radiology·E M Marom, C A Helms
Sep 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·C M GabrielR A Hughes
Oct 16, 2002·Stereotactic and Functional Neurosurgery·V Rajshekhar
Nov 18, 2008·Neurosurgery Clinics of North America·Kimberly K AmramiRobert J Spinner
Jan 24, 2009·Chirurgie de la main·C OberlinH Asfazadourian
Jul 2, 2009·Brain : a Journal of Neurology·Michelle L MauermannP James B Dyck
May 18, 2010·Acta neurochirurgica·Marie-Noëlle Hébert-BlouinRobert J Spinner
Aug 9, 2011·Journal of Neurosurgery·Marie-Noëlle Hébert-BlouinRobert J Spinner
Aug 21, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·J B AgadiS K Shankar
Nov 24, 2012·The Journal of Hand Surgery·Christopher J DyScott W Wolfe
May 7, 2013·Journal of Neurosurgery·Marie-Noëlle Hébert-BlouinRobert J Spinner
Jun 12, 2013·Skeletal Radiology·Benjamin Matthew HoweRobert J Spinner

❮ Previous
Next ❯

Citations

Jun 9, 2016·Pediatric Neurology·Cristiane M IdaChristopher J Klein
Oct 13, 2016·Skeletal Radiology·Gavin A McKenzieMichael D Ringler
Mar 2, 2017·Neurosurgical Focus·Pierre LaumonerieRobert J Spinner
Dec 7, 2017·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Tomas MarekRobert J Spinner
Apr 28, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Tomas MarekRobert J Spinner
Jan 23, 2019·Skeletal Radiology·Anthony H DeVriesStephen M Broski
Jun 17, 2020·Neurosurgery·Sarada Sakamuri, Thomas J Wilson
Oct 13, 2018·Nature Reviews. Disease Primers·Bernd C KieseierHans-Peter Hartung
Feb 9, 2017·Neurosurgery·Nikhil K PrasadRobert J Spinner
Feb 26, 2021·Muscle & Nerve·Dev NathaniMatthew C Kiernan
Jul 27, 2021·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Robert J Spinner

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
dissection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.