Targeted full energy and protein delivery in critically ill patients: a study protocol for a pilot randomised control trial (FEED Trial)

Pilot and Feasibility Studies
Kate FetterplaceChristopher MacIsaac

Abstract

Current guidelines for the provision of protein for critically ill patients are based on incomplete evidence, due to limited data from randomised controlled trials. The present pilot randomised controlled trial is part of a program of work to expand knowledge about the clinical effects of protein delivery to critically ill patients. The primary aim of this pilot study is to determine whether an enteral feeding protocol using a volume target, with additional protein supplementation, delivers a greater amount of protein and energy to mechanically ventilated critically ill patients than a standard nutrition protocol. The secondary aims are to evaluate the potential effects of this feeding strategy on muscle mass and other patient-centred outcomes. This prospective, single-centred, pilot, randomised control trial will include 60 participants who are mechanically ventilated and can be enterally fed. Following informed consent, the participants receiving enteral nutrition in the intensive care unit (ICU) will be allocated using a randomisation algorithm in a 1:1 ratio to the intervention (high-protein daily volume-based feeding protocol, providing 25 kcal/kg and 1.5 g/kg protein) or standard care (hourly rate-based feeding protocol p...Continue Reading

Associated Clinical Trials

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Citations

Apr 28, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Kate FetterplaceChristopher MacIsaac

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Methods Mentioned

BETA
SGA

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
SPSS® Statistics Premium Grad Pack
Stata
Stata Corporation

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