Targeted genome editing in acute lymphoblastic leukemia: a review

BMC Biotechnology
Adrián MontañoRocío Benito

Abstract

Genome editing technologies offers new opportunities for tackling diseases such as acute lymphoblastic leukemia (ALL) that have been beyond the reach of previous therapies. We show how the recent availability of genome-editing tools such as CRISPR-Cas9 are an important means of advancing functional studies of ALL through the incorporation, elimination and modification of somatic mutations and fusion genes in cell lines and mouse models. These tools not only broaden the understanding of the involvement of various genetic alterations in the pathogenesis of the disease but also identify new therapeutic targets for future clinical trials. New approaches including CRISPR-Cas9 are crucial for functional studies of genetic aberrations driving cancer progression, and that may be responsible for treatment resistance and relapses. By using this approach, diseases can be more faithfully reproduced and new therapeutic targets and approaches found.

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Citations

Jan 29, 2019·Frontiers in Bioengineering and Biotechnology·Larissa Pereira BrumanoAdalberto Pessoa Junior
May 1, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Hussein SabitAfnan Al-Muhanaa
Jul 16, 2021·Biological Procedures Online·Ziyi ZhaoYi Sang

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Methods Mentioned

BETA
genetic modification
acetylation
exome sequencing
xenograft

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