Targeted HFpEF therapy based on matchmaking of human and animal models

American Journal of Physiology. Heart and Circulatory Physiology
Arantxa Barandiarán AizpuruaVanessa van Empel

Abstract

The diversity in clinical phenotypes and poor understanding of the underlying pathophysiology of heart failure with preserved ejection fraction (HFpEF) is the main reason why no effective treatments have been found yet. Targeted, instead of one size fits all, treatment seems the only promising approach for treating HFpEF. To be able to design a targeted, phenotype-specific HFpEF treatment, the matrix relating clinical phenotypes and underlying pathophysiological mechanisms has to be clarified. This review discusses the opportunities for additional evaluation of the underlying pathophysiological processes, e.g., to evaluate biological phenotypes on top of clinical routine, to guide us toward a phenotype-specific HFpEF treatment. Moreover, a translational approach with matchmaking of animal models to biological HFpEF phenotypes will be a valuable step to test the effectiveness of novel, targeted interventions in HFpEF. Listen to this article's corresponding podcast at https://ajpheart.podbean.com/e/personalized-medicine-in-hfpef/ .

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Citations

Mar 19, 2020·Experimental Biology and Medicine·Maria L Loredo-MendozaFrancisco Villarreal
Jun 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bochra TourkiGanesh V Halade
Aug 22, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Lydia E MatesicFrancis G Spinale
Feb 12, 2021·Nature Reviews. Cardiology·Begoña LópezJavier Díez
Nov 19, 2021·Journal of Applied Physiology·Rachel C KelleyLeonardo F Ferreira

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Methods Mentioned

BETA
imaging techniques
biopsies
biopsy

Clinical Trials Mentioned

NCT02173548
NCT02576678
NCT01212770
NCT03057951
NCT03030235
NCT02901184
NCT03133793

Software Mentioned

HFpEF

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