Targeted Lesion Generation Through the Skull Without Aberration Correction Using Histotripsy

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Jonathan SukovichCharles A Cain

Abstract

This study demonstrates the ability of histotripsy to generate targeted lesions through the skullcap without using aberration correction. Histotripsy therapy was delivered using a 500 kHz, 256-element hemispherical transducer with an aperture diameter of 30 cm and a focal distance of 15 cm fabricated in our lab. This transducer is theoretically capable of producing peak rarefactional pressures, based on linear estimation, (p-)LE, in the free field in excess of 200MPa with pulse durations 2 acoustic cycles. Three excised human skullcaps were used displaying attenuations of 73-81% of the acoustic pressure without aberration correction. Through all three skullcaps, compact lesions with radii less than 1mm were generated in red blood cell (RBC) agarose tissue phantoms without aberration correction, using estimated (p-)LE of 28-39MPa, a pulse repetition frequency of 1Hz, and a total number of 300 pulses. Lesion generation was consistently observed at the geometric focus of the transducer as the position of the skullcap with respect to the transducer was varied, and multiple patterned lesions were generated transcranially by mechanically adjusting the position of the skullcap with respect to the transducer to target different regions...Continue Reading

Citations

Aug 6, 2016·Physics in Medicine and Biology·Kullervo Hynynen, Ryan M Jones
Nov 30, 2018·Journal of Neurosurgery·Jonathan R SukovichZhen Xu
Dec 12, 2020·Advanced Science·Roland Beisteiner, Andres M Lozano
Apr 4, 2021·Journal of Clinical Medicine·Antonio D'AmmandoFrancesco Prada
Apr 9, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Zhen XuFred T Lee
Sep 1, 2021·Ultrasound in Medicine & Biology·Lauren ArnoldEli Vlaisavljevich

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