Targeted metabolomic approach in men with carotid plaque

PloS One
Teresa AuguetCristóbal Richart

Abstract

The aim of the study was to analyse the presence of several metabolites related to atherosclerosis in the plasma of patients with unstable carotid plaque and in the plasma of healthy subjects. We included 20 patients who had undergone carotid endarterectomy and 20 healthy subjects as a control group. All the subjects recruited were male. We used a metabolomic approach with liquid chromatography coupled to mass spectrometry to evaluate plasma metabolite levels in the metabolic pathway involved in the progression of atherosclerotic plaque. We observed that circulating levels of 20-HETE were significantly higher in patients with atheroma plaque than in healthy subjects (p = 0.018). No differences were found with regard to the other metabolites analysed. We also conducted a random forest analysis and found that 20-HETE was the main differentiator in the list of selected metabolites. In addition, plasma levels of 20-HETE correlated positively with body mass index (r = 0.427, p = 0.007) and diastolic blood pressure (r = 0.365, p = 0.028). This study confirms that of all the molecules studied only 20-HETE is related to carotid plaque. Further studies are needed to compare patients with stable carotid plaque vs. patients with unstable ...Continue Reading

References

Dec 14, 2005·Circulation·Marc S SabatineRobert E Gerszten
Oct 20, 2007·The Journal of Pharmacology and Experimental Therapeutics·Tsuneo IshizukaMichal Laniado-Schwartzman
Jan 31, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yanhua ZhangNalini Sadagopan
Sep 28, 2010·Lancet·Alison HallidayUNKNOWN Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group
Feb 3, 2012·Physiological Reviews·John D Imig
Sep 27, 2012·Journal of Cardiovascular Pharmacology·Jeremy Bellien, Robinson Joannides
Nov 12, 2013·Vascular and Endovascular Surgery·Joseph ShalhoubAlun H Davies
Dec 5, 2014·Neurology·Mariona JovéFrancisco Purroy
Mar 31, 2015·Prostaglandins & Other Lipid Mediators·Samantha L HoopesDarryl C Zeldin
Jul 3, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Maksim ZaguraMihkel Zilmer
May 28, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P A VorkasE Holmes
Jul 9, 2016·BMC Cardiovascular Disorders·Teresa AuguetCristóbal Richart

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Citations

Aug 9, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ankit GilaniMichal Laniado Schwartzman
Sep 14, 2019·International Journal of Molecular Sciences·Shashank ShekharFan Fan
Mar 3, 2019·International Journal of Molecular Sciences·Zahra Solati, Amir Ravandi
May 11, 2021·Frontiers in Cardiovascular Medicine·D Elizabeth LeSanjiv Kaul

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Software Mentioned

SPSS / PC +
R
R package
HOMA Calculator
ConsensusPathDB
DiHET

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