Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients.

Journal of Lipid Research
Diana SchmerlerMichael Kiehntopf

Abstract

The occurrence of systemic inflammatory response syndrome (SIRS) remains a major problem in intensive care units with high morbidity and mortality. The differentiation between noninfectious and infectious etiologies of this disorder is challenging in routine clinical practice. Many biomarkers have been suggested for this purpose; however, sensitivity and specificity even of high-ranking biomarkers remain insufficient. Recently, metabolic profiling has attracted interest for biomarker discovery. The objective of this study was to identify metabolic biomarkers for differentiation of SIRS/sepsis. A total of 186 meta-bolites comprising six analyte classes were determined in 143 patients (74 SIRS, 69 sepsis) by LC-MS/MS. Two markers (C10:1 and PCaaC32:0) revealed significantly higher concentrations in sepsis. A classification model comprising these markers resulted in 80% and 70% correct classifications in a training set and a test set, respectively.This study demonstrates that acylcarnitines and glycerophosphatidylcholines may be helpful for differentiation of infectious from noninfectious systemic inflammation due to their significantly higher concentration in sepsis patients. Considering the well known pathophysiological relevanc...Continue Reading

References

Sep 28, 1979·Biochimica Et Biophysica Acta·P CalderonJ Christophe
Jul 1, 1987·The Journal of Clinical Investigation·K R Feingold, C Grunfeld
Sep 1, 1996·The British Journal of Surgery·J S SamraK N Frayn
Aug 29, 1998·Intensive Care Medicine·M MeisnerJ Schüttler
Dec 9, 1998·Digestive Surgery·H B ReithA Thiede
Apr 29, 2000·Intensive Care Medicine·C Brun-Buisson
Aug 25, 2001·Journal of Endotoxin Research·H W HarrisZ L Kumwenda
Feb 4, 2003·Journal of Lipid Research·Wolfgang DrobnikGerd Schmitz
Nov 27, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chieko Mitaka
Feb 24, 2007·The Lancet Infectious Diseases·Benjamin M P TangAnthony S McLean
Jun 25, 2008·Journal of Lipid Research·Kenneth R FeingoldCarl Grunfeld
May 16, 2009·Journal of Lipid Research·Kenneth R FeingoldCarl Grunfeld
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Jun 21, 2011·Critical Care : the Official Journal of the Critical Care Forum·Allison SutherlandDeon Venter

❮ Previous
Next ❯

Citations

Aug 27, 2013·Current Infectious Disease Reports·Keith R Walley
Oct 5, 2012·Clinical Microbiology Reviews·Konrad ReinhartChristiane S Hartog
May 3, 2013·American Journal of Respiratory and Critical Care Medicine·Michael KiehntopfMichael Bauer
Oct 7, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Angelica DessìVassilios Fanos
Jul 25, 2013·Expert Review of Anti-infective Therapy·Eirini Christaki
May 24, 2016·EBioMedicine·Richard D SembaMark J Manary
Jan 2, 2015·BMJ Open Respiratory Research·Longxiang SuLixin Xie
Feb 11, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joris R Delanghe, Marijn M Speeckaert
Mar 18, 2016·Critical Care : the Official Journal of the Critical Care Forum·David Antcliffe, Anthony C Gordon
Mar 4, 2014·Clinical Genetics·E Christaki, E J Giamarellos-Bourboulis
Aug 16, 2015·Infection·Martin E RichterMichael Kiehntopf
Jul 15, 2015·Bioanalysis·Mengying LvFengguo Xu
Jul 8, 2015·Critical Care : the Official Journal of the Critical Care Forum·Claudia C Dos Santos
Sep 14, 2014·Analytical and Bioanalytical Chemistry·Peng Gao, Guowang Xu
Jun 15, 2016·Scientific Reports·Richard D SembaMark J Manary
Apr 21, 2016·Critical Care Medicine·Sophie NeugebauerMichael Kiehntopf
Oct 23, 2013·Analytical Chemistry·Shama NazCoral Barbas
Feb 17, 2017·Molecular BioSystems·Katelyn R Ludwig, Amanda B Hummon
Jun 21, 2016·Journal of Pediatric Gastroenterology and Nutrition·Richard D SembaMark J Manary
May 17, 2017·Critical Care Medicine·Timothy E Sweeney, Purvesh Khatri
Jun 3, 2017·Pediatric Research·Pui-Ying Iroh Tam, Catherine M Bendel
Mar 2, 2016·International Journal of Molecular Sciences·Susanna K P LauPatrick C Y Woo
Jun 28, 2018·The Journal of Clinical Endocrinology and Metabolism·Richard D SembaLuigi Ferrucci
Oct 7, 2015·Infection and Immunity·Chinh T Q NguyenAnthony W Maresso
Nov 16, 2012·Nature·Jeremy K NicholsonJohn C Lindon
Dec 19, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Kenneth B Christopher
Feb 23, 2020·Metabolites·Henna JaurilaTero I Ala-Kokko
Oct 23, 2019·The Journal of Applied Laboratory Medicine·Khushbu Patel, Erin McElvania
Jul 3, 2019·Clinical and Experimental Medicine·Agnieszka KlupczynskaJan Matysiak
Jun 13, 2020·Expert Review of Molecular Diagnostics·Ellen HaagPhilipp Schuetz
Jul 28, 2020·Molecular & Cellular Proteomics : MCP·Khyatiben V PathakPatrick Pirrotte
Apr 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ruin MoaddelLuigi Ferrucci
Sep 5, 2020·Metabolites·Giovana Colozza MecattiPatrícia de Oliveira Carvalho
Dec 31, 2018·Critical Care : the Official Journal of the Critical Care Forum·Pär I JohanssonKenneth B Christopher
Nov 9, 2019·Cancer Immunology, Immunotherapy : CII·Andreas MockCarsten Grüllich

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