Targeted Molecular Imaging Using Aptamers in Cancer

Pharmaceuticals
Sorah Yoon, John J Rossi

Abstract

Imaging is not only seeing, but also believing. For targeted imaging modalities, nucleic acid aptamers have features such as superior recognition of structural epitopes and quick uptake in target cells. This explains the emergence of an evolved new class of aptamers into a wide spectrum of imaging applications over the last decade. Genetically encoded biosensors tagged with fluorescent RNA aptamers have been developed as intracellular imaging tools to understand cellular signaling and physiology in live cells. Cancer-specific aptamers labeled with fluorescence have been used for assessment of clinical tissue specimens. Aptamers conjugated with gold nanoparticles have been employed to develop innovative mass spectrometry tissue imaging. Also, use of chemically conjugated cancer-specific aptamers as probes for non-invasive and high-resolution imaging has been transformative for in vivo imaging in multiple cancers.

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Citations

Jan 6, 2019·Pharmaceuticals·Sarah Shigdar
Dec 28, 2018·Pharmaceuticals·Umair KhalidSarah Shigdar
Feb 27, 2021·Analytical Biochemistry·Kosar ShahsavarGuobao Xu
Jul 3, 2021·International Journal of Molecular Sciences·Chris ViSarah Shigdar
Oct 31, 2021·Cell Biochemistry and Biophysics·Fatemeh HeidariNosratollah Zarghami

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Methods Mentioned

BETA
imaging techniques
biosensors
biosensor
fluorescence microscopy
fluorescence-activated cell sorting
in vitro transcription
imaging technique
irradiate
fluorescence imaging
X-ray

Clinical Trials Mentioned

NCT03385148
NCT02957370

Software Mentioned

Spinach
iSpinach

Related Concepts

Related Feeds

Biosensors for Cancer Detection

Biosensors are devices that are designed to detect a specific biological analyte by essentially converting a biological entity (ie, protein, DNA, RNA) into an electrical signal that can be detected and analyzed. The use of biosensors in cancer detection and monitoring holds vast potential. Biosensors can be designed to detect emerging cancer biomarkers and to determine drug effectiveness at various target sites. Biosensor technology has the potential to provide fast and accurate detection, reliable imaging of cancer cells, and monitoring of angiogenesis and cancer metastasis, and the ability to determine the effectiveness of anticancer chemotherapy agents.

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