Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

Nature Genetics
M AdachiS Nagata

Abstract

Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (lpr) mutation is a leaky mutation in Fas. By means of gene targeting, we generated a mouse strain which is completely deficient in Fas. In addition to the massive production of lymphocytes, the Fas-null mice showed substantial liver hyperplasia, which was accompanied by the enlargement of nuclei in hepatocytes. The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs.

References

Jan 1, 1991·Annual Review of Cell Biology·R E EllisH R Horvitz
Aug 11, 1991·Nucleic Acids Research·P W LairdA Berns
Jan 1, 1991·Annual Review of Immunology·P L Cohen, R A Eisenberg
Apr 1, 1988·Liver·N ArberI Ariel
Jun 1, 1988·Liver·A BenedettiF Orlandi
Jun 3, 1967·Nature·C J Epstein, E A Gatens
Dec 1, 1994·Experimental Cell Research·R NiS Nagata
Dec 1, 1994·European Journal of Immunology·S M MarianiP H Krammer
Jan 1, 1995·The Journal of Experimental Medicine·M R AldersonD H Lynch
Feb 1, 1995·The Journal of Experimental Medicine·J OgasawaraS Nagata
Feb 1, 1995·The Journal of Experimental Medicine·F VignauxP Golstein
Mar 10, 1995·Science·S Nagata, P Golstein
Jan 1, 1995·Immunology Today·S Nagata, T Suda
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M AdachiS Nagata
Mar 15, 1993·Biochemical and Biophysical Research Communications·S KobayashiT Uede
Aug 1, 1993·The Journal of Experimental Medicine·J WuJ D Mountz
Aug 26, 1993·Nature·J OgasawaraS Nagata
Nov 1, 1993·The Journal of Experimental Medicine·K AndoF V Chisari
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J H RussellR Wang

❮ Previous
Next ❯

Citations

Feb 14, 1998·Journal of Cellular Physiology·A FineN L Anderson
May 1, 1997·Molecular Reproduction and Development·K SakamakiS Yonehara
May 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C G Print, K L Loveland
Jan 6, 2001·Molecular Reproduction and Development·A L Kierszenbaum
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R A Rippe
Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·Caroline Lambert, Julie Desbarats
Oct 24, 2007·Apoptosis : an International Journal on Programmed Cell Death·Sun-Mi ParkMarcus E Peter
Apr 25, 2007·Apoptosis : an International Journal on Programmed Cell Death·Klas BlomgrenLaurent Groc
Apr 2, 2013·Trends in Molecular Medicine·Ana Martin-VillalbaDamian Wollny
Apr 20, 2005·Neurobiology of Disease·Pascal MilletFrançois D Boussin
Oct 24, 2002·Biochemical Pharmacology·Gil MorMarijke Kamsteeg
Dec 18, 2001·Mechanisms of Ageing and Development·Yingpei Zhang, Brian Herman
Oct 10, 2001·Biochimica Et Biophysica Acta·M ZörnigG Evan
Feb 18, 1999·Toxicology Letters·P H Krammer
Aug 15, 2002·Experimental Gerontology·Yingpei ZhangBrian Herman
Dec 18, 1998·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G FeldmannA Bringuier
Oct 30, 1998·Cellular Signalling·J R Orlinick, M V Chao
Apr 1, 1996·Current Opinion in Immunology·A M Kruisbeek, D Amsen
Apr 1, 1996·Current Opinion in Immunology·B A Osborne
Jun 1, 1996·Current Opinion in Immunology·L Van Parijs, A K Abbas
Feb 19, 2000·Current Opinion in Neurobiology·C RaoulC E Henderson
Jun 6, 2003·Cytokine & Growth Factor Reviews·Hae-ock Lee, Thomas A Ferguson
Oct 1, 1996·Cytokine & Growth Factor Reviews·J Oppenheim, H Fujiwara
May 3, 2003·Trends in Molecular Medicine·Peter M Kang, Seigo Izumo
Mar 1, 1996·Nature Medicine·M TanakaS Nagata
Jul 2, 1998·Clinical and Experimental Immunology·S JodoT Koike
Oct 30, 1999·Clinical and Experimental Immunology·T L PanC L Chen
Dec 22, 1999·Journal of Viral Hepatitis·N Hayashi, E Mita
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marcus SchuchmannPeter R Galle
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Priscilla L YangFrancis V Chisari
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·J DesbaratsM K Newell
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·M AdachiS Nagata
Feb 11, 2009·The Journal of Biological Chemistry·Hongxia Z ImtiyazJianke Zhang
Sep 22, 1998·The Journal of Experimental Medicine·J Q RussellR C Budd
Apr 14, 2004·The Journal of Experimental Medicine·Stephan MathasBernd Dörken
Sep 1, 2005·The Journal of Experimental Medicine·Anne M LandauJulie Desbarats
Sep 4, 2013·The Journal of Experimental Medicine·Mario KreutzfeldtDoron Merkler
Jun 10, 2004·Cancer Biotherapy & Radiopharmaceuticals·Hubert VermeerschChristophe Van de Wiele
Feb 3, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Réda Hadj-SlimanePierre Bobé

❮ Previous
Next ❯

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