Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan

Biomaterials
Tao JiangChong-Su Cho

Abstract

M cells, the key players of the mucosal immunity induction, are one of the intestinal barriers for the efficient delivery of vaccines to mucosal immune tissues. To overcome the barrier, we have developed an efficient oral vaccine carrier that constitutes poly (lactic-co-glycolic acid) (PLGA) microparticle coated with M cell targeting peptide. In this study, a membrane protein B of Brachyspira hyodysenteriae (BmpB) as a model vaccine against swine dysentery was loaded into porous PLGA microparticles (MPs). The PLGA MPs were further coated with the water-soluble chitosan (WSC) conjugated with M cell homing peptide (CKS9) to prepare BmpB-CKS9-WSC-PLGA MPs. Oral immunization of BmpB vaccine with CKS9-WSC-PLGA MPs in mice showed elevated secretory IgA responses in the mucosal tissues and systemic IgG antibody responses, providing a complete immune response. Specifically, the immunization with these MPs demonstrated to induce both Th1- and Th2-type responses based on elevated IgG1 and IgG2a titers. The elevated immune responses were attributed to the enhanced M cell targeting and transcytosis ability of CKS9-WSC-PLGA MPs to Peyer's patch regions. The high binding affinity of CKS9-WSC-PLGA MPs with the M cells to enter into the Peyer'...Continue Reading

References

Jun 20, 1997·Science·D A EdwardsR Langer
Jun 6, 2000·Advanced Drug Delivery Reviews·R LangerJ Hanes
Aug 3, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S Romagnani
Aug 23, 2001·Advanced Drug Delivery Reviews·L IllumS S Davis
Oct 31, 2003·Critical Reviews in Therapeutic Drug Carrier Systems·Ram I MahatoDuane D Miller
Apr 7, 2005·Nature Medicine·Jan Holmgren, Cecil Czerkinsky
Dec 22, 2005·Infection and Immunity·Peter TyrerJennelle M Kyd
May 11, 2007·Expert Opinion on Drug Delivery·Mayank D Bhavsar, Mansoor M Amiji
Jul 3, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Matthew M ArnoldCory Berkland
Jul 24, 2007·Human Vaccines·A Ruth FoxwellJennelle M Kyd
Oct 24, 2007·Biomaterials·Ana JaklenecEdith Mathiowitz
Jan 4, 2008·Journal of Drug Targeting·Bram SlütterWim Jiskoot
Oct 8, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Soon Eon BaeDong Keun Han
Apr 22, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Owen I Corrigan, Xue Li
Nov 21, 2009·Advanced Drug Delivery Reviews·Maryam AmidiWim E Hennink
Jun 18, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jangwook LeeKuen Yong Lee
Nov 19, 2010·PLoS Pathogens·Ali AziziJiri Mestecky
Jun 5, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Olga Kammona, Costas Kiparissides
Dec 29, 2012·International Journal of Nanomedicine·Mohammad Ariful IslamChong-Su Cho
Feb 23, 2013·International Journal of Pharmaceutics·Jwala RenukuntlaAshim K Mitra
Jun 15, 2013·Chemical Society Reviews·Martin Hartmann, Xenia Kostrov

❮ Previous
Next ❯

Citations

Jul 16, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tao JiangYun-Jaie Choi
Jan 1, 2014·Vaccines·Weidang LiAshlesh K Murthy
Jun 26, 2014·Expert Opinion on Drug Delivery·Xiuying LiMingshi Yang
Dec 17, 2014·Pharmaceutical Development and Technology·Jakub VysloužilKateřina Dvořáčková
Apr 12, 2016·Colloids and Surfaces. B, Biointerfaces·Baoxia LiuDecheng Wu
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Mevyn NizardEric Tartour
Mar 21, 2015·Journal of Materials Science. Materials in Medicine·Jinxie ZhangLaiqiang Huang
May 3, 2014·Drug Discovery Today·Udita AgrawalSuresh P Vyas
May 8, 2016·International Journal of Pharmaceutics·Juntao YinXiaoyong Song
Oct 30, 2015·Human Vaccines & Immunotherapeutics·Mojgan Allahyari, Elham Mohit
May 30, 2016·Colloids and Surfaces. B, Biointerfaces·Ya LiuXi-Guang Chen
May 20, 2016·Drug Discovery Today·Miaorong YuYong Gan
Jun 12, 2016·International Journal of Biological Macromolecules·Ping GaoXiguang Chen
Jan 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lei XingChong-Su Cho
Sep 15, 2018·Human Vaccines & Immunotherapeutics·Miguel F Carvalho, Davinder Gill
Jun 22, 2019·Advanced Materials·Matilde Durán-LobatoMaría José Alonso
Aug 27, 2014·Expert Review of Vaccines·Nirmal MarasiniIstvan Toth
Oct 18, 2019·Biomaterials Science·Xiankang HuJianxiang Zhang
May 20, 2017·Frontiers in Microbiology·Vanessa CasasJoaquin Abian
Nov 23, 2018·International Journal of Molecular Sciences·Bijay SinghChong-Su Cho
Jan 6, 2019·The Journal of Pharmacology and Experimental Therapeutics·Hyunjoon KimJayanth Panyam
Mar 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Joshua D SnookJai S Rudra
Mar 23, 2018·Frontiers in Immunology·Blaise Corthésy, Gilles Bioley
Apr 11, 2020·Tissue Engineering. Part a·Alexander M Tatara
Oct 27, 2017·Pathogens and Disease·Jason Byron D S PerezJanet E Hill
May 30, 2020·Annual Review of Pharmacology and Toxicology·Jacob William CoffeyGiovanni Traverso
Nov 16, 2018·Biomaterials·Mohammad Ariful IslamChong Su Cho
Oct 16, 2020·Progress in Biomaterials·Elena LagrecaRaffaele Vecchione
Mar 7, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shaoqi QuKui Zhu
May 8, 2018·International Journal of Pharmaceutics·Md Jasim Uddin, Harvinder Singh Gill
Jun 15, 2018·International Journal of Pharmaceutics·Daiki NomuraMakiya Nishikawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.